uu.seUppsala universitets publikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Can routine outpatient follow-up of patients with bladder cancer be improved?: A multicenter prospective observational assessment of blue light flexible cystoscopy and fulguration
Vestre Viken HF Baerum Hosp, Dept Urol, Oslo, Norway.
Lund Univ, Skane Univ Hosp, Dept Urol, Malmo, Sweden.
Univ Copenhagen, Herlev & Gentofte Hosp, Dept Urol, Copenhagen, Denmark.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Urologkirurgi.ORCID-id: 0000-0001-8572-9957
2018 (Engelska)Ingår i: Research and Reports in Urology, ISSN 2253-2447, E-ISSN 1179-1551, Vol. 10, s. 151-157Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: The aim of this prospective cohort study was to determine the feasibility of incorporating blue light flexible cystoscopy (BLFC) and biopsy/fulguration into routine outpatient follow-up of non-muscle invasive bladder cancer patients.

Methods: The study included patients with non-muscle-invasive bladder cancer (NMIBC) who were scheduled for routine follow-up. Hexaminolevulinate was instilled in the outpatient department, and the bladder was examined under white light and then with BLFC. Biopsies were taken from all suspicious lesions. Small tumors and suspicious lesions were fulgurated on site; patients with larger lesions were referred to the operating room for resection.

Results: The study included 69 patients, with a mean age of 70 years (range 33 -89 years) and a mean duration since NMIBC diagnosis of 8 years. Most patients had high-grade cancer at initial diagnosis (52/69) and were at high risk of recurrence (48/69). Two patients per hour could be assessed using outpatient BLFC. Preparation and instillation of hexaminolevulinate took less than 10 minutes per patient, and patients had an additional waiting time of 45 60 minutes following instillation, while the hexaminolevulinate solution was retained in the bladder before examination. Eleven patients had histologically confirmed tumors that were identified using both white light flexible cystoscopy and BLFC. An additional three patients had tumors that were identified by BLFC only: two with Ta tumors and one with carcinoma in situ. Of the 14 patients with confirmed tumors, 11 could be managed on site with fulguration, whereas three were referred to the operating room. No adverse events attributable to BLFC were reported.

Conclusion: Routine outpatient management of patients with NMIBC using BLFC and onsite biopsy/fulguration is feasible, despite the additional time required for hexaminolevulinate instillation, and appears to allow early detection of recurrent lesions, which can be fulgurated without the need for hospitalization.

Ort, förlag, år, upplaga, sidor
DOVE MEDICAL PRESS LTD , 2018. Vol. 10, s. 151-157
Nyckelord [en]
bladder cancer, blue light, diagnosis, flexible cystoscopy, hexaminolevulinate, outpatients
Nationell ämneskategori
Urologi och njurmedicin
Identifikatorer
URN: urn:nbn:se:uu:diva-368771DOI: 10.2147/RRU.S141314ISI: 000447216900001PubMedID: 30349812OAI: oai:DiVA.org:uu-368771DiVA, id: diva2:1269442
Tillgänglig från: 2018-12-10 Skapad: 2018-12-10 Senast uppdaterad: 2018-12-10Bibliografiskt granskad

Open Access i DiVA

fulltext(687 kB)65 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 687 kBChecksumma SHA-512
b9f00c2435543bf1ad8ad31ab3daf94d6371effb5fe7f14be06c10699fbcf2702f68fcfe24600409cd82252cda3943ee77e1223323cebd6b0e4d478501da0d70
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Malmström, Per-Uno

Sök vidare i DiVA

Av författaren/redaktören
Malmström, Per-Uno
Av organisationen
Urologkirurgi
I samma tidskrift
Research and Reports in Urology
Urologi och njurmedicin

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 65 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 70 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf