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Protein Profiling in Serum and Cerebrospinal Fluid Following Complex Surgery on the Thoracic Aorta Identifies Biological Markers of Neurologic Injury.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Thoraxkirurgi.ORCID-id: 0000-0001-7913-4981
Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Molekylära verktyg.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Molekylära verktyg. Uppsala universitet, Science for Life Laboratory, SciLifeLab.ORCID-id: 0000-0002-7820-1000
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2018 (engelsk)Inngår i: Journal of Cardiovascular Translational Research, ISSN 1937-5387, E-ISSN 1937-5395, Vol. 11, nr 6, s. 503-516Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Surgery on the arch or descending aorta is associated with significant risk of neurological complications. As a consequence of intubation and sedation, early neurologic injury may remain unnoticed. Biomarkers to aid in the initial diagnostics could prove of great value as immediate intervention is critical. Twenty-three patients operated in the thoracic aorta with significant risk of perioperative neurological injury were included. Cerebrospinal fluid (CSF) and serum were obtained preoperatively and in the first and second postoperative days and assessed with a panel of 92 neurological-related proteins. Three patients suffered spinal cord injury (SCI), eight delirium, and nine hallucinations. There were markers in both serum and CSF that differed between the affected and non-affected patients (SCI; IL6, GFAP, CSPG4, delirium; TR4, EZH2, hallucinations; NF1). The study identifies markers in serum and CSF that reflect the occurrence of neurologic insults following aortic surgery, which may aid in the care of these patients.

sted, utgiver, år, opplag, sider
2018. Vol. 11, nr 6, s. 503-516
Emneord [en]
Biomarkers, Cardiovascular surgery, Neurologic injury, Thoracic aortic disease
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Identifikatorer
URN: urn:nbn:se:uu:diva-369702DOI: 10.1007/s12265-018-9835-8ISI: 000453355000007PubMedID: 30367354OAI: oai:DiVA.org:uu-369702DiVA, id: diva2:1271146
Tilgjengelig fra: 2018-12-16 Laget: 2018-12-16 Sist oppdatert: 2019-01-15bibliografisk kontrollert

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