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Temporal relationship of sleep apnea and acromegaly: a nationwide study
Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.ORCID iD: 0000-0002-9501-6763
Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrinology and mineral metabolism.
Karolinska Inst, Dept Mol Med & Surg, Patient Area Endocrinol & Nephrol Inflammat & Inf, Stockholm, Sweden;Karolinska Univ Hosp, Stockholm, Sweden.
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2018 (English)In: Endocrine (Basingstoke), ISSN 1355-008X, E-ISSN 1559-0100, Vol. 62, no 2, p. 456-463Article in journal (Refereed) Published
Abstract [en]

Purpose: Patients with acromegaly have an increased risk of sleep apnea, but reported prevalence rates vary largely. Here we aimed to evaluate the sleep apnea prevalence in a large national cohort of patients with acromegaly, to examine possible risk factors, and to assess the proportion of patients diagnosed with sleep apnea prior to acromegaly diagnosis.

Methods: Cross-sectional multicenter study of 259 Swedish patients with acromegaly. At patients' follow-up visits at the endocrine outpatient clinics of all seven university hospitals in Sweden, questionnaires were completed to assess previous sleep apnea diagnosis and treatment, cardiovascular diseases, smoking habits, anthropometric data, and S-IGF-1 levels. Daytime sleepiness was evaluated using the Epworth Sleepiness Scale. Patients suspected to have undiagnosed sleep apnea were referred for sleep apnea investigations.

Results: Of the 259 participants, 75 (29%) were diagnosed with sleep apnea before the study start. In 43 (57%) of these patients, sleep apnea had been diagnosed before the diagnosis of acromegaly. After clinical assessment and sleep studies, sleep apnea was diagnosed in an additional 20 patients, yielding a total sleep apnea prevalence of 37%. Higher sleep apnea risk was associated with higher BMI, waist circumference, and index finger circumference. Sleep apnea was more frequent among patients with S-IGF-1 levels in the highest quartile.

Conclusion: Sleep apnea is common among patients with acromegaly, and is often diagnosed prior to their acromegaly diagnosis. These results support early screening for sleep apnea in patients with acromegaly and awareness for acromegaly in patients with sleep apnea.

Place, publisher, year, edition, pages
2018. Vol. 62, no 2, p. 456-463
Keywords [en]
Acromegaly, Sleep apnea, Comorbidities, Risk factors
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-369590DOI: 10.1007/s12020-018-1694-1ISI: 000449306400022PubMedID: 30066288OAI: oai:DiVA.org:uu-369590DiVA, id: diva2:1272568
Available from: 2018-12-19 Created: 2018-12-19 Last updated: 2018-12-19Bibliographically approved

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Forsgren, MariaEdén Engström, Britt

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