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Humanistic outcomes in treatment resistant depression: a secondary analysis of the STAR*D study
Janssen Res & Dev LLC, Titusville, NJ 08560 USA.
Janssen Res & Dev LLC, Titusville, NJ 08560 USA.
Janssen Res & Dev LLC, Titusville, NJ 08560 USA.
Janssen Res & Dev LLC, Titusville, NJ 08560 USA.
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2018 (engelsk)Inngår i: BMC Psychiatry, ISSN 1471-244X, E-ISSN 1471-244X, Vol. 18, artikkel-id 352Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BackgroundIn the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, a third of patients did not achieve remission or adequate response after two treatment trials, fulfilling requirements for treatment resistant depression (TRD). The present study is a secondary analysis of the STAR*D data conducted to compare the humanistic outcomes in patients with TRD and non-TRD MDD.MethodsPatients with major depressive disorder who entered level 3 of the STAR*D were included in the TRD group, while patients who responded to treatment and entered follow-up from level 1 or 2 were included in the non-TRD group. The first visit in level 1 was used for baseline assessments. The time-point of assessments for comparison was the first visit in level 3 for TRD patients (median day: 141), and the visit closest to 14160days from baseline for non-TRD patients. Outcomes were assessed by the 12-item Short Form Health Survey (SF12), 16-item Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), Work and Social Adjustment Scale (WSAS), and Work Productivity and Activity Impairment scale (WPAI). Scores were compared in a linear model with adjustment for covariates including age, gender, and depression severity measured by the 17-item Hamilton Rating Scale for Depression (HDRS17) and Quick Inventory of Depressive Symptomatology (QIDS).ResultsA total of 2467 (TRD: 377; non-TRD: 2090) patients were studied. TRD patients were slightly older (mean age 44 vs 42years), had a higher proportion of men (49% vs 37%, p<.0001), and baseline depression severity (HDRS17: 24.4 vs 22.0, p<.0001) vs non-TRD patients. During follow-up, TRD patients had lower health-related quality of life (HRQOL) scores on mental (30 vs 45.7) and physical components (47.7 vs 48.9) of the SF12, and lower Q-LES-Q scores (43.6 vs 63.7), greater functional and work impairments and productivity loss vs non-TRD patients (all p<0.05).Conclusion Patients with TRD had worse HRQOL, work productivity, and social functioning than the non-TRD patients.

sted, utgiver, år, opplag, sider
BMC , 2018. Vol. 18, artikkel-id 352
Emneord [en]
Health-related quality of life, Humanistic outcomes, Social functioning, Star*d, Treatment resistant depression
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Identifikatorer
URN: urn:nbn:se:uu:diva-369888DOI: 10.1186/s12888-018-1920-7ISI: 000448750800001PubMedID: 30373547OAI: oai:DiVA.org:uu-369888DiVA, id: diva2:1272612
Forskningsfinansiär
Swedish Research Council, 2016-02362Tilgjengelig fra: 2018-12-19 Laget: 2018-12-19 Sist oppdatert: 2018-12-19bibliografisk kontrollert

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