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Right ventricular involvement in transthyretin amyloidosis
Umea Univ, Heart Ctr, Dept Clin Physiol, Umea, Sweden.
Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiologi.
Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
Vise andre og tillknytning
2018 (engelsk)Inngår i: Amyloid: Journal of Protein Folding Disorders, ISSN 1350-6129, E-ISSN 1744-2818, Vol. 25, nr 3, s. 160-166Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: The extent of right ventricular (RV) involvement in transthyretin amyloidosis (ATTR) is unknown.Objectives: This study sought to establish the degree of RV involvement in ATTR amyloidosis, and compare findings with RV involvement in hypertrophic cardiomyopathy (HCM).Methods: Forty-two patients with ATTR amyloidosis and echocardiographic evidence of cardiac amyloidosis (cardiac ATTR), 19 ATTR patients with normal left ventricular (LV) wall thickness (non-cardiac ATTR), 25 patients with diagnosed HCM and 30 healthy controls were included in this study. Echocardiographic measurements for conventional parameters, as well as RV global and segmental strain, were recorded.Results: When comparing RV structure and function between cardiac ATTR amyloidosis and HCM patients, only segmental strain differed between the two groups. In cardiac ATTR amyloidosis, we found an RV apex-to-base strain gradient with highest deformation in the apex. This pattern was reversed in patients with HCM.Conclusions: RV involvement is common in cardiac ATTR patients. The present study also detected an RV apical sparing pattern in patients with ATTR cardiomyopathy, similar to what has previously been described for the left ventricle in these patients. This pattern was not seen in HCM patients. Further studies are needed to assess the clinical importance of these findings.

sted, utgiver, år, opplag, sider
TAYLOR & FRANCIS LTD , 2018. Vol. 25, nr 3, s. 160-166
Emneord [en]
Hypertrophic cardiomyopathy, apical sparing, strain, amyloid cardiomyopathy, right ventricle
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-372684DOI: 10.1080/13506129.2018.1493989ISI: 000451980700004PubMedID: 30193533OAI: oai:DiVA.org:uu-372684DiVA, id: diva2:1276681
Forskningsfinansiär
Swedish Heart Lung FoundationVästerbotten County Council, VLL 365301Tilgjengelig fra: 2019-01-08 Laget: 2019-01-08 Sist oppdatert: 2019-01-08bibliografisk kontrollert

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