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A Modular Approach to Sensitized Two-Photon Patterning of Photodegradable Hydrogels
TU Wien, Inst Mat Sci & Technol, Getreidemarkt 9-308, A-1060 Vienna, Austria;TU Wien, Inst Appl Synthet Chem, Getreidemarkt 9-163-MC, A-1060 Vienna, Austria;Austrian Cluster Tissue Regenerat, Vienna, Austria.ORCID iD: 0000-0002-8052-6517
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
TU Wien, Inst Lightweight Design & Struct Biomech, Getreidemarkt 9-317, A-1060 Vienna, Austria;Austrian Cluster Tissue Regenerat, Vienna, Austria.
TU Wien, Inst Mat Sci & Technol, Getreidemarkt 9-308, A-1060 Vienna, Austria;Austrian Cluster Tissue Regenerat, Vienna, Austria.
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2018 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 57, no 46, p. 15122-15127Article in journal (Refereed) Published
Abstract [en]

Photodegradable hydrogels have emerged as useful platforms for research on cell function, tissue engineering, and cell delivery as their physical and chemical properties can be dynamically controlled by the use of light. The photo-induced degradation of such hydrogel systems is commonly based on the integration of photolabile o-nitrobenzyl derivatives to the hydrogel backbone, because such linkers can be cleaved by means of one-and two-photon absorption. Herein we describe a cytocompatible click-based hydrogel containing o-nitrobenzyl ester linkages between a hyaluronic acid backbone, which is photodegradable in the presence of cells. It is demonstrated for the first time that by using a cyclic benzylidene ketone-based small molecule as photosensitizer the efficiency of the two-photon degradation process can be improved significantly. Biocompatibility of both the improved two-photon micropatterning process as well as the hydrogel itself is confirmed by cell culture studies.

Place, publisher, year, edition, pages
WILEY-V C H VERLAG GMBH , 2018. Vol. 57, no 46, p. 15122-15127
Keywords [en]
biomaterials, hyaluronic acid, hydrogels, photochemistry, sensitizers
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-372823DOI: 10.1002/anie.201808908ISI: 000452396800023PubMedID: 30191643OAI: oai:DiVA.org:uu-372823DiVA, id: diva2:1277016
Available from: 2019-01-09 Created: 2019-01-09 Last updated: 2019-01-09Bibliographically approved

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Shi, LiyangOssipov, Dmitri A.

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