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Cervical dysplasia in elderly women performing repeated self-sampling for HPV testing
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Center for Clinical Research Dalarna. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health. Örebro Univ, Clin Res Ctr, Fac Med & Hlth, Örebro, Sweden.ORCID iD: 0000-0002-7407-9642
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Reproductive biology. Örebro Univ, Fac Med & Hlth, Dept Oncol, Örebro, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
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2018 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 12, article id e0207714Article in journal (Refereed) Published
Abstract [en]

Background About 30% of the cervical cancer cases in Sweden occur in women older than 60. The primary aim was to evaluate the acceptability of repeated self-sampling at home for HPV-testing in elderly women. The prevalence of HPV and HPV related dysplasia as well as the sensitivity of cytology was evaluated. Methods Repeated self-sampling at home for HPV testing was offered 375 women in each of the four age groups 60, 65, 70 and 75 years. Women with two consecutive positive HPV tests were examined with sampling for histology and cytology. Findings A self-sample was provided by 59.5% (893/1500) of the invited women. The overall prevalence of HPV was 4.4% (95% CI 3.2-6.0, n = 39) in the first test, and 2.5% were persistent positive in the second test (95% C 1.6-3.8, n = 22) collected on average 5.5 months later. Dysplasia, was found in 1.8% (16/893) (95% CI 1.1-3.0) and CIN 2+ in 1.0% (9/893) (95% CI 0.5-2.0) of the women. Of the 16 women with dysplasia in histology, 13 (81.2%) had a normal cytology. Interpretation Repeated self-sampling at home combined with HPV testing was well accepted among elderly women. A high prevalence of CIN was diagnosed by histology. Cytology showed extremely low sensitivity and should not be recommended for this age group.

Place, publisher, year, edition, pages
2018. Vol. 13, no 12, article id e0207714
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Obstetrics, Gynecology and Reproductive Medicine
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URN: urn:nbn:se:uu:diva-372761DOI: 10.1371/journal.pone.0207714ISI: 000452212400061PubMedID: 30517176OAI: oai:DiVA.org:uu-372761DiVA, id: diva2:1278395
Available from: 2019-01-14 Created: 2019-01-14 Last updated: 2019-01-14Bibliographically approved

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Lindström, AnnikaGustavsson, Inger M.Lindberg, Julia HedlundGyllensten, Ulf B.Olovsson, Matts

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Lindström, AnnikaSanchez Hermansson, RuthGustavsson, Inger M.Lindberg, Julia HedlundGyllensten, Ulf B.Olovsson, Matts
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Center for Clinical Research DalarnaDepartment of Women's and Children's HealthReproductive biologyMedicinsk genetik och genomik
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