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Mitochondrial oxidative stress in obesity: role of the mineralocorticoid receptor
Paris Descartes Univ, Pierre & Marie Curie Univ, INSERM, Ctr Rech Cordeliers, UMRS 1138, Paris, France.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrative Physiology.
Paris Descartes Univ, Pierre & Marie Curie Univ, INSERM, Ctr Rech Cordeliers,UMRS 1138, Paris, France.ORCID iD: 0000-0002-0867-1277
Paris Descartes Univ, Pierre & Marie Curie Univ, INSERM, Ctr Rech Cordeliers,UMRS 1138, Paris, France.
2018 (English)In: Journal of Endocrinology, ISSN 0022-0795, E-ISSN 1479-6805, Vol. 238, no 3, p. R143-R159Article, review/survey (Refereed) Published
Abstract [en]

Obesity is a multifaceted, chronic, low-grade inflammation disease characterized by excess accumulation of dysfunctional adipose tissue. It is often associated with the development of cardiovascular (CV) disorders, insulin resistance and diabetes. Under pathological conditions like in obesity, adipose tissue secretes bioactive molecules called 'adipokines', including cytokines, hormones and reactive oxygen species (ROS). There is evidence suggesting that oxidative stress, in particular, the ROS imbalance in adipose tissue, may be the mechanistic link between obesity and its associated CV and metabolic complications. Mitochondria in adipose tissue are an important source of ROS and their dysfunction contributes to the pathogenesis of obesity-related type 2 diabetes. Mitochondrial function is regulated by several factors in order to preserve mitochondria integrity and dynamics. Moreover, the renin-angiotensin-aldosterone system is over-activated in obesity. In this review, we focus on the pathophysiological role of the mineralocorticoid receptor in the adipose tissue and its contribution to obesity-associated metabolic and CV complications. More specifically, we discuss whether dysregulation of the mineralocorticoid system within the adipose tissue may be the upstream mechanism and one of the early events in the development of obesity, via induction of oxidative stress and mitochondrial dysfunction, thus impacting on systemic metabolism and the CV system.

Place, publisher, year, edition, pages
2018. Vol. 238, no 3, p. R143-R159
Keywords [en]
mineralocorticoid receptor, adipose tissue, mitochondrial dysfunction, oxidative stress, obesity
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-373538DOI: 10.1530/JOE-18-0163ISI: 000451042500003PubMedID: 29875164OAI: oai:DiVA.org:uu-373538DiVA, id: diva2:1280894
Funder
The Wenner-Gren FoundationMagnus Bergvall Foundation√Öke Wiberg FoundationAvailable from: 2019-01-21 Created: 2019-01-21 Last updated: 2019-01-21Bibliographically approved

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