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Unmet Medical Needs in Pulmonary Neuroendocrine (Carcinoid) Neoplasms
Inst Gustave Roussy, Oncol Endocrinienne & Med Nucl, Villejuif, France.
Royal Free Hosp, Neuroendocrine Tumour Unit, London, England.
Univ Lyon, Dept Pathol, Lyon, France.
Univ Torino, Dept Thorac Surg, Turin, Italy.
Vise andre og tillknytning
2019 (engelsk)Inngår i: Neuroendocrinology, ISSN 0028-3835, E-ISSN 1423-0194, Vol. 108, nr 1, s. 7-17Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Pulmonary carcinoids (PCs) display the common features of all well-differentiated neuroendocrine neoplasms (NEN) and are classified as low- and intermediate-grade malignant tumours (i.e., typical and atypical carcinoid, respectively). There is a paucity of randomised studies dedicated to advanced PCs and management principles are drawn from the larger gastroenteropancreatic NEN experience. There is growing evidence that NEN anatomic subgroups have different biology and different responses to treatment and, therefore, should be investigated as separate entities in clinical trials. In this review, we discuss the existing evidence and limitations of tumour classification, diagnostics and staging, prognostication, and treatment in the setting of PC, with focus on unmet medical needs and directions for the future.

sted, utgiver, år, opplag, sider
2019. Vol. 108, nr 1, s. 7-17
Emneord [en]
Bronchial carcinoid tumours, NET, Neuroendocrine neoplasms, Pulmonary carcinoids
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-375567DOI: 10.1159/000493980ISI: 000456048400002PubMedID: 30248673OAI: oai:DiVA.org:uu-375567DiVA, id: diva2:1284191
Merknad

ENETS 2016 Munich Advisory Board Participants (UU authors): Jenny Falkerby; Anders Sundin; Eva Tiensuu Janson & Staffan Welin

Tilgjengelig fra: 2019-01-31 Laget: 2019-01-31 Sist oppdatert: 2019-02-11bibliografisk kontrollert

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