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Postmortem magnetic resonance imaging vs autopsy of second trimester fetuses terminated due to anomalies
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning i Sörmland (CKFD).ORCID iD: 0000-0001-6856-3465
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology.ORCID iD: 0000-0002-9481-6857
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Obstetrics and Reproductive Health Research.ORCID iD: 0000-0003-4394-8769
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
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2019 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 98, no 7, p. 865-876Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: Our aim was to investigate the accuracy of postmortem fetal magnetic resonance imaging (MRI) compared to fetal autopsy in second trimester pregnancies terminated due to fetal anomalies. A secondary aim was to compare the MRI evaluations of two senior radiologists.

MATERIAL AND METHODS: This was a prospective study including 34 fetuses from pregnancies terminated in the second trimester due to fetal anomalies. All women accepted a postmortem MRI and an autopsy of the fetus. Two senior radiologists performed independent evaluations of the MRI images. A senior pathologist performed the fetal autopsies. The degree of concordance between the MRI evaluations and the autopsy reports was estimated as well as the consensus between the radiologists.

RESULTS: Thirty-four fetuses were evaluated. Sixteen cases were associated with the central nervous system (CNS), five musculoskeletal, one cardiovascular, one urinary tract, and 11 cases had miscellaneous anomalies such as chromosomal aberrations, infections, and syndromes. In the 16 cases related to the CNS, both radiologists reported all or some, including the most clinically significant anomalies in 15 (94%; CI 70-100%) cases. In the 18 non-CNS cases, both radiologists reported all or some, including the most clinically significant anomalies in six (33%; CI 5-85%) cases. In 21 cases (62%; CI 44-78%) cases, both radiologists held opinions that were consistent with the autopsy reports. The degree of agreement between the radiologists was high, with a Cohen's Kappa of 0.87.

CONCLUSIONS: Postmortem fetal MRI can replace autopsy for second trimester fetuses with CNS anomalies. For non-CNS anomalies, the concordance is lower but postmortem MRI can still be of value when autopsy is not an option.

Place, publisher, year, edition, pages
2019. Vol. 98, no 7, p. 865-876
Keywords [en]
Fetal anomalies, Fetal diagnosis, Post-mortem fetal MRI, Prenatal diagnosis, Prospective study, Second trimester
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:uu:diva-375605DOI: 10.1111/aogs.13548ISI: 000472678200006PubMedID: 30694559OAI: oai:DiVA.org:uu-375605DiVA, id: diva2:1284277
Funder
Swedish Society of MedicineAvailable from: 2019-01-31 Created: 2019-01-31 Last updated: 2019-09-13Bibliographically approved

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Hellkvist, AnnaWikström, JohanMulic-Lutvica, AjlanaLindgren, PeterPenno, EvaAxelsson, Ove

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Centrum för klinisk forskning i Sörmland (CKFD)RadiologyObstetrics and Reproductive Health ResearchDepartment of Immunology, Genetics and PathologyDepartment of Women's and Children's Health
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Radiology, Nuclear Medicine and Medical Imaging

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