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The enigmatic ribosomal stalk
Lund Univ, Dept Biochem & Struct Biol, Ctr Chem & Chem Engn, Lund, Sweden.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Biology.ORCID iD: 0000-0002-7124-792X
2018 (English)In: Quarterly reviews of biophysics (Print), ISSN 0033-5835, E-ISSN 1469-8994, Vol. 51, article id e12Article, review/survey (Refereed) Published
Abstract [en]

The large ribosomal subunit has a distinct feature, the stalk, extending outside the ribosome. In bacteria it is called the L12 stalk. The base of the stalk is protein uL10 to which two or three dimers of proteins bL12 bind. In archea and eukarya P1 and P2 proteins constitute the stalk. All these extending proteins, that have a high degree of flexibility due to a hinge between their N- and C-terminal parts, are essential for proper functionalization of some of the translation factors. The role of the stalk proteins has remained enigmatic for decades but is gradually approaching an understanding. In this review we summarise the knowhow about the structure and function of the ribosomal stalk till date starting from the early phase of ribosome research.

Place, publisher, year, edition, pages
Cambridge University Press, 2018. Vol. 51, article id e12
Keywords [en]
Ribosomal stalk, bL12, P1/P2, translational GTPases (trGTPases)
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-374867DOI: 10.1017/S0033583518000100ISI: 000455259600001OAI: oai:DiVA.org:uu-374867DiVA, id: diva2:1284279
Funder
Swedish Research Council, 2014-4423Swedish Research Council, 2016-06264Knut and Alice Wallenberg Foundation, KAW 2017.0055Available from: 2019-01-31 Created: 2019-01-31 Last updated: 2019-01-31Bibliographically approved

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Sanyal, Suparna

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