uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Bursting onto the scene?: Exploring stochastic mRNA production in bacteria
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Systems Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Systems Biology.ORCID iD: 0000-0001-5522-1810
2018 (English)In: Current Opinion in Microbiology, ISSN 1369-5274, E-ISSN 1879-0364, Vol. 45, p. 124-130Article, review/survey (Refereed) Published
Abstract [en]

Recent large-scale measurements of gene expression variability (or noise) in E. coli have led to the unexpected conclusion that the variability is in large part dictated by and increasing with the mean level of expression. Here we review the evidence for this apparent universal trend in variability, as well as for the related idea that transcription is fundamentally bursty. We examine recently proposed mechanisms for burstiness and universality and argue that they do not explain important features of observed data. Finally, we discuss potential limitations and pitfalls in the interpretation of experimental measurements of cell-to-cell variability.

Place, publisher, year, edition, pages
CURRENT BIOLOGY LTD , 2018. Vol. 45, p. 124-130
National Category
Microbiology
Identifiers
URN: urn:nbn:se:uu:diva-375611DOI: 10.1016/j.mib.2018.04.001ISI: 000454972700019PubMedID: 29705632OAI: oai:DiVA.org:uu-375611DiVA, id: diva2:1284329
Funder
Swedish Research Council, VR 642-2013-7841Swedish Research Council, VR 621-2012-4027EU, European Research Council, ERC-2013-CoG/616047EU, Horizon 2020, MSCA-IF-2015-704206Available from: 2019-01-31 Created: 2019-01-31 Last updated: 2019-01-31Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Jones, DanielElf, Johan

Search in DiVA

By author/editor
Jones, DanielElf, Johan
By organisation
Molecular Systems BiologyScience for Life Laboratory, SciLifeLab
In the same journal
Current Opinion in Microbiology
Microbiology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 53 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf