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Bursting onto the scene?: Exploring stochastic mRNA production in bacteria
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär systembiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
Uppsala universitet, Science for Life Laboratory, SciLifeLab. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för cell- och molekylärbiologi, Molekylär systembiologi.ORCID-id: 0000-0001-5522-1810
2018 (engelsk)Inngår i: Current Opinion in Microbiology, ISSN 1369-5274, E-ISSN 1879-0364, Vol. 45, s. 124-130Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Recent large-scale measurements of gene expression variability (or noise) in E. coli have led to the unexpected conclusion that the variability is in large part dictated by and increasing with the mean level of expression. Here we review the evidence for this apparent universal trend in variability, as well as for the related idea that transcription is fundamentally bursty. We examine recently proposed mechanisms for burstiness and universality and argue that they do not explain important features of observed data. Finally, we discuss potential limitations and pitfalls in the interpretation of experimental measurements of cell-to-cell variability.

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CURRENT BIOLOGY LTD , 2018. Vol. 45, s. 124-130
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URN: urn:nbn:se:uu:diva-375611DOI: 10.1016/j.mib.2018.04.001ISI: 000454972700019PubMedID: 29705632OAI: oai:DiVA.org:uu-375611DiVA, id: diva2:1284329
Forskningsfinansiär
Swedish Research Council, VR 642-2013-7841Swedish Research Council, VR 621-2012-4027EU, European Research Council, ERC-2013-CoG/616047EU, Horizon 2020, MSCA-IF-2015-704206Tilgjengelig fra: 2019-01-31 Laget: 2019-01-31 Sist oppdatert: 2019-01-31bibliografisk kontrollert

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