uu.seUppsala universitets publikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Changes of arterial pressure following relief of obstruction in adults with hydronephrosis
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Barnkirurgisk forskning.ORCID-id: 0000-0001-9578-1783
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Urologkirurgi.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Barnkirurgisk forskning.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Urologkirurgi.
Vise andre og tillknytning
2018 (engelsk)Inngår i: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 123, nr 4, s. 216-224Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: As much as 20% of all cases of hypertension are associated with kidney malfunctions. We have previously demonstrated in animals and in pediatric patients that hydronephrosis causes hypertension, which was attenuated by surgical relief of the ureteropelvic junction (UPJ) obstruction. This retrospective cohort study aimed to investigate: (1) the proposed link between hydronephrosis, due to UPJ obstruction, and elevated arterial pressure in adults; and (2) if elevated blood pressure in patients with hydronephrosis might be another indication for surgery.

Materials and methods: Medical records of 212 patients undergoing surgical management of hydronephrosis, due to UPJ obstruction, between 2000 and 2016 were assessed. After excluding patients with confounding conditions and treatments, paired arterial pressures (i.e. before/after surgery) were compared in 49 patients (35 years old; 95% CI 29–39). Split renal function was evaluated by using mercaptoacetyltriglycine (MAG3) renography before surgical management of the hydronephrotic kidney.

Results: Systolic (−11 mmHg; 95% CI 6–15 mmHg), diastolic (−8 mmHg; 95% CI 4–11 mmHg), and mean arterial (-9 mmHg; 95% CI 6–12) pressures were significantly reduced after relief of the obstruction (p < 0.001). Split renal function of the hydronephrotic kidney was 39% (95% CI 37–41). No correlations were found between MAG3 and blood pressure level before surgery or between MAG3 and the reduction of blood pressure after surgical management of the UPJ obstruction.

Conclusions: In adults with hydronephrosis, blood pressure was reduced following relief of the obstruction. Our findings suggest that elevated arterial pressure should be taken into account as an indication to surgically correct hydronephrosis.

sted, utgiver, år, opplag, sider
2018. Vol. 123, nr 4, s. 216-224
Emneord [en]
Blood pressure, hydronephrosis, hypertension, kidney, renal function, ureteral obstruction
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-375862DOI: 10.1080/03009734.2018.1521890ISI: 000455702800004PubMedID: 30293474OAI: oai:DiVA.org:uu-375862DiVA, id: diva2:1285110
Forskningsfinansiär
Swedish Research Council, 2016-01381Swedish Research Council, 65X-03522-43-3Swedish Heart Lung Foundation, 20140448; 20170124Tilgjengelig fra: 2019-02-01 Laget: 2019-02-01 Sist oppdatert: 2019-02-01bibliografisk kontrollert

Open Access i DiVA

fulltekst(1884 kB)59 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 1884 kBChecksum SHA-512
a600dff12449609f671dcdb0f99ce450f6c695300837a893616f61b99e38b6584341de1765bc4a323c3b3f12edc6a050b42e478d9e56571515445f85cca393ab
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Al-Mashhadi, AmmarHäggman, MichaelLäckgren, GöranLadjevardi, SamNevéus, TryggveStenberg, ArnePersson, A. Erik G.

Søk i DiVA

Av forfatter/redaktør
Al-Mashhadi, AmmarHäggman, MichaelLäckgren, GöranLadjevardi, SamNevéus, TryggveStenberg, ArnePersson, A. Erik G.Carlstrom, Mattias
Av organisasjonen
I samme tidsskrift
Upsala Journal of Medical Sciences

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 59 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 553 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf