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Sequencing of Hepatitis C Virus for Detection of Resistance to Direct-Acting Antiviral Therapy: A Systematic Review
Univ New South Wales, Kirby Inst, Sydney, NSW 2052, Australia.ORCID iD: 0000-0003-0699-2250
Univ New South Wales, Kirby Inst, Sydney, NSW 2052, Australia.
Univ New South Wales, Kirby Inst, Sydney, NSW 2052, Australia;Univ New South Wales, Fac Med, Sch Med Sci, Sydney, NSW, Australia.
Monogram Biosci, Lab Corp Amer Holdings, San Francisco, CA USA.
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2017 (English)In: HEPATOLOGY COMMUNICATIONS, ISSN 2471-254X, Vol. 1, no 5, p. 379-390Article, review/survey (Refereed) Published
Abstract [en]

The significance of the clinical impact of direct-acting antiviral (DAA) resistance-associated substitutions (RASs) in hepatitis C virus (HCV) on treatment failure is unclear. No standardized methods or guidelines for detection of DAA RASs in HCV exist. To facilitate further evaluations of the impact of DAA RASs in HCV, we conducted a systematic review of RAS sequencing protocols, compiled a comprehensive public library of sequencing primers, and provided expert guidance on the most appropriate methods to screen and identify RASs. The development of standardized RAS sequencing protocols is complicated due to a high genetic variability and the need for genotype- and subtype-specific protocols for multiple regions. We have identified several limitations of the available methods and have highlighted areas requiring further research and development. The development, validation, and sharing of standardized methods for all genotypes and subtypes should be a priority.

Place, publisher, year, edition, pages
JOHN WILEY & SONS LTD , 2017. Vol. 1, no 5, p. 379-390
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Gastroenterology and Hepatology
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URN: urn:nbn:se:uu:diva-377409DOI: 10.1002/hep4.1050ISI: 000453171800003PubMedID: 29404466OAI: oai:DiVA.org:uu-377409DiVA, id: diva2:1290357
Available from: 2019-02-20 Created: 2019-02-20 Last updated: 2019-02-20Bibliographically approved

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Lennerstrand, Johan

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