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Hyaluronan-binding protein 2 (HABP2) gene variation in women with recurrent miscarriage
Karolinska Inst, Danderyds Hosp, Div Obstet & Gynaecol, Dept Clin Sci, Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.
Competence Ctr Hlth Technol, Tartu, Estonia;Univ Granada, Dept Biochem & Mol Biol, Fac Sci, Granada, Spain.
Karolinska Inst, Danderyds Hosp, Div Obstet & Gynaecol, Dept Clin Sci, Stockholm, Sweden.
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2018 (English)In: BMC Women's Health, ISSN 1472-6874, E-ISSN 1472-6874, Vol. 18, article id 143Article in journal (Refereed) Published
Abstract [en]

Background:

Idiopathic recurrent miscarriage, defined as three or more consecutive miscarriages, is a distressing early pregnancy complication. Although, the etiology of recurrent miscarriage is still unknown, an aberrant regulation of the endometrial receptivity marker hyaluronan-binding protein 2 (HABP2) has been suggested. The objective of the present study was to investigate the effect of genetic variations of HABP2 in women with idiopathic recurrent miscarriage compared to fertile women.

Methods:

This study was designed as a case-control study. In total, 165 women who had three or more consecutive miscarriages and 289 fertile women were included in the study. Polymorphisms in the HABP2 gene were analyzed using TaqMan SNP Genotyping Assays. Three polymorphisms in the HABP2 gene, rs1157916, rs2240879 and rs7080536 (Marburg I) were studied.

Results:

Polymorphism in HABP2 showed no significant difference in women with recurrent miscarriage compared to fertile women, except for rs1157916 minor A allele that was more prevalent among RM patients (p = 0.058). Significantly higher live birth rate was observed among women with three to four miscarriages compared to those with more miscarriages (p = 0.001).

Conclusions:

Variations in the HABP2 gene did not seem to be involved in the etiology of recurrent miscarriage, while, the number of previous miscarriages had an impact on the live birth rate.

Place, publisher, year, edition, pages
2018. Vol. 18, article id 143
Keywords [en]
Genotype, Hyaluronan-binding protein2 (HABP2), Recurrent miscarriage
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:uu:diva-379249DOI: 10.1186/s12905-018-0618-9ISI: 000460040400001PubMedID: 30143058OAI: oai:DiVA.org:uu-379249DiVA, id: diva2:1296583
Available from: 2019-03-15 Created: 2019-03-15 Last updated: 2019-03-15Bibliographically approved

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Åkerud, HelenaSundström Poromaa, IngerStavreus-Evers, Anneli

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