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Serum glucose, triglycerides, and cholesterol in relation to prostate cancer death in the Swedish AMORIS study
Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, New York, NY 10461 USA;Kings Coll London, Translat Oncol & Urol Res, London, England;Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, 1300 Morris Pk, Bronx, NY 10461 USA.ORCID-id: 0000-0002-3241-2945
Kings Coll London, Translat Oncol & Urol Res, London, England.ORCID-id: 0000-0001-8200-5929
Kings Coll London, Translat Oncol & Urol Res, London, England;Uppsala Univ Hosp, Dept Surg Sci, Uppsala, Sweden.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Endokrinkirurgi. Umea Univ, Dept Biobank Res, Umea, Sweden.
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2019 (Engelska)Ingår i: Cancer Causes and Control, ISSN 0957-5243, E-ISSN 1573-7225, Vol. 30, nr 2, s. 195-206Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Purpose: Lifestyle-related conditions such as obesity are associated with prostate cancer progression, but the associations with hyperglycemia and dyslipidemia are unclear. This study, therefore, aims to examine the association of glucose, triglycerides, and total cholesterol with prostate cancer death

Methods: From the Swedish AMORIS cohort, we selected 14,150 men diagnosed with prostate cancer between 1996 and 2011 who had prediagnostic measurements of serum glucose, triglycerides, and total cholesterol. Multivariable Cox proportional hazards regressionmodels were used to determine the hazard ratios for death in relation to the aforementioned metabolic markers.

Results: Using clinical cut-off points, a non-significant positive association was observed between glucose and prostate cancer death. When compared to those with glucose in the lowest quartile, those in the highest quartile had greater risk of prostate cancer death (HR 1.19; 95% CI 1.02-1.39). However, neither total cholesterol nor triglycerides were associated with prostate cancer death. Glucose and triglycerides were positively associated with overall, cardiovascular, and other deaths. Hypercholesterolemia was only associated with risk of CVD death.

Conclusion: Our results suggest that glucose levels may influence prostate cancer survival, but further studies using repeated measurements are needed to further elucidate how glucose levels may influence prostate cancer progression.

Ort, förlag, år, upplaga, sidor
SPRINGER , 2019. Vol. 30, nr 2, s. 195-206
Nyckelord [en]
Prostate cancer, Glucose, Triglycerides, Total cholesterol, AMORIS
Nationell ämneskategori
Cancer och onkologi
Identifikatorer
URN: urn:nbn:se:uu:diva-379277DOI: 10.1007/s10552-018-1093-1ISI: 000459153800009PubMedID: 30421156OAI: oai:DiVA.org:uu-379277DiVA, id: diva2:1296772
Forskningsfinansiär
Forte, Forskningsrådet för hälsa, arbetsliv och välfärdCancerfondenTillgänglig från: 2019-03-18 Skapad: 2019-03-18 Senast uppdaterad: 2019-12-12Bibliografiskt granskad

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Häggström, ChristelStattin, Pär

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