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Human ROBO1 regulates white matter structure in corpus callosum.
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2017 (English)In: Brain Structure and Function, ISSN 1863-2653, E-ISSN 1863-2661, Vol. 222, no 2, p. 707-716Article in journal (Refereed) Published
Abstract [en]

The axon guidance receptor, Robo1, controls the pathfinding of callosal axons in mice. To determine whether the orthologous ROBO1 gene is involved in callosal development also in humans, we studied polymorphisms in the ROBO1 gene and variation in the white matter structure in the corpus callosum using both structural magnetic resonance imaging and diffusion tensor magnetic resonance imaging. We found that five polymorphisms in the regulatory region of ROBO1 were associated with white matter density in the posterior part of the corpus callosum pathways. One of the polymorphisms, rs7631357, was also significantly associated with the probability of connections to the parietal cortical regions. Our results demonstrate that human ROBO1 may be involved in the regulation of the structure and connectivity of posterior part of corpus callosum.

Place, publisher, year, edition, pages
2017. Vol. 222, no 2, p. 707-716
Keywords [en]
Axon guidance receptor homolog 1, Axonal pathfinding, DTI, Roundabout, Single nucleotide polymorphism, Structural MRI
National Category
Medical Genetics
Research subject
Molecular Genetics
Identifiers
URN: urn:nbn:se:uu:diva-373449DOI: 10.1007/s00429-016-1240-yPubMedID: 27240594OAI: oai:DiVA.org:uu-373449DiVA, id: diva2:1301093
Available from: 2019-04-01 Created: 2019-04-01 Last updated: 2019-11-12

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