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Three dyslexia susceptibility genes, DYX1C1, DCDC2, and KIAA0319, affect temporo-parietal white matter structure.
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2012 (English)In: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 72, no 8, p. 671-6, article id S0006-3223(12)00445-3Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Volume and integrity of white matter correlate with reading ability, but the underlying factors contributing to this variability are unknown.

METHODS: We investigated single nucleotide polymorphisms in three genes previously associated with dyslexia and implicated in neuronal migration (DYX1C1, DCDC2, KIAA0319) and white matter volume in a cohort of 76 children and young adults from the general population.

RESULTS: We found that all three genes contained polymorphisms that were significantly associated with white matter volume in the left temporo-parietal region and that white matter volume influenced reading ability.

CONCLUSIONS: The identified region contained white matter pathways connecting the middle temporal gyrus with the inferior parietal lobe. The finding links previous neuroimaging and genetic results and proposes a mechanism underlying variability in reading ability in both normal and impaired readers.

Place, publisher, year, edition, pages
2012. Vol. 72, no 8, p. 671-6, article id S0006-3223(12)00445-3
National Category
Medical Genetics
Research subject
Molecular Genetics
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URN: urn:nbn:se:uu:diva-373460DOI: 10.1016/j.biopsych.2012.05.008PubMedID: 22683091OAI: oai:DiVA.org:uu-373460DiVA, id: diva2:1301169
Available from: 2019-04-01 Created: 2019-04-01 Last updated: 2019-04-01

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