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Spring peaks and autumn troughs identified in peripheral inflammatory markers during the peripartum period
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Obstetrisk och reproduktiv hälsoforskning.
Norwegian Institute of Public Health, Oslo, Norway.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Obstetrisk och reproduktiv hälsoforskning.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Obstetrisk och reproduktiv hälsoforskning. Karolinska Institutet, Stockholm, Sweden.ORCID-id: 0000-0001-9010-8522
Vise andre og tillknytning
2019 (engelsk)Inngår i: Scientific Reports, E-ISSN 2045-2322, Vol. 9, artikkel-id 15328Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Seasonal variations have recently been described in biomarkers, cell types, and gene expression associated with the immune system, but so far no studies have been conducted among women in the peripartum period. It is of note that pregnancy complications and outcomes, as well as autoimmune diseases, have also been reported to exhibit seasonal fluctuations. We report here a clear-cut seasonal pattern of 23 inflammatory markers, analysed using proximity-extension assay technology, in pregnant women. The inflammatory markers generally peaked in the spring and had a trough in the autumn. During the postpartum period we found seasonality in one inflammatory marker, namely monocyte chemotactic protein 4 (MCP-4). Our findings suggest that seasonal variations in peripheral inflammatory markers are only observed during pregnancy. The results of this study could be valuable to professionals working within the field of immunology-related areas, and provide insight for the understanding of obstetric complications.

sted, utgiver, år, opplag, sider
2019. Vol. 9, artikkel-id 15328
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-381420DOI: 10.1038/s41598-019-51527-9ISI: 000492825800038PubMedID: 31653981OAI: oai:DiVA.org:uu-381420DiVA, id: diva2:1303329
Forskningsfinansiär
Swedish Society of Medicine, 523-2014-2342 521-2013-2339Marianne and Marcus Wallenberg Foundation, MMW2011.0115Swedish Research Council, 523-2014-2342Swedish Research Council, 521-2013-2339Tilgjengelig fra: 2019-04-09 Laget: 2019-04-09 Sist oppdatert: 2022-09-15bibliografisk kontrollert
Inngår i avhandling
1. Seasonal aspects of peripartum depressive symptoms
Åpne denne publikasjonen i ny fane eller vindu >>Seasonal aspects of peripartum depressive symptoms
2019 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Every year, a large proportion of pregnant and newly delivered women develop peripartum depression, a condition that may cause long-term suffering for the entire family. Although there is a lack of consensus, some studies propose an association between season and the risk of developing depression during pregnancy and the postpartum period. Furthermore, the immune system, which undergoes numerous structural changes during pregnancy, has been suggested to exhibit seasonal variations. In addition, discrepancies in metabolic profiles have been reported between women with and without depression after childbirth. This thesis aimed to investigate seasonal aspects of peripartum depressive symptoms (PPDS) and biological markers during the peripartum period. The data mainly derived from the prospective population-based Biology, Affect, Stress, Imaging, and Cognition (BASIC) study, but data were also included from the longitudinal population-based Uppsala-Athens (UPPSAT) study. The presence of depressive symptoms was primarily assessed using the Edinburgh Postnatal Depression Scale (EPDS). There were no consistent associations between season, meteorological parameters, air pollen count, and PPDS. Moreover, a number of inflammatory markers were identified as having seasonal variations among samples from pregnant women. On the contrary, only one marker had a seasonal pattern during the early postpartum period. Furthermore, metabolic profiles were not discriminatory between pregnant women with and without depressive symptoms. However, when divided into summer and winter childbirths, discrepancies were identified in metabolic profiles between summer cases and controls, as well as between summer and winter controls. In summary, the studies included in this thesis suggest that season, specifically, is not associated with PPDS. However, season may have a moderating effect on the association between depressive symptoms and the metabolic profile of pregnant women. In addition, the seasonal variations appears more prominent among inflammatory markers during late pregnancy, compared with the early postpartum period. These findings suggest that women need equal attention in clinical care regardless of the season during which they give birth. Future studies on biological aspects of PPDS and immune-associated conditions are encouraged to also assess seasonality.

sted, utgiver, år, opplag, sider
Uppsala: Acta Universitatis Upsaliensis, 2019. s. 70
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 1573
Emneord
peripartum depressive symptoms, pregnancy, postpartum, seasonality, meteorological parameters, inflammatory markers, proximity extension assay, metabolomics, gas chromatography-mass spectrometry
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-381426 (URN)978-91-513-0658-2 (ISBN)
Disputas
2019-06-12, lecture hall IX, University Main Building, Biskopsgatan 3, Uppsala, 09:15 (engelsk)
Opponent
Veileder
Tilgjengelig fra: 2019-05-21 Laget: 2019-04-17 Sist oppdatert: 2019-06-17

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Henriksson, Hanna E.Iliadis, Stavros IFransson, EmmaPapadopoulos, FotiosSundström Poromaa, IngerSkalkidou, Alkistis

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