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Exploring the use of amine modified mesoporous magnesium carbonate for the delivery of salicylic acid in topical formulations: in vitro cytotoxicity and drug release studies
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Nanoteknologi och funktionella material.
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2019 (Engelska)Ingår i: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 24, nr 9, artikel-id 1820Artikel i tidskrift (Refereegranskat) Published
Ort, förlag, år, upplaga, sidor
MDPI, 2019. Vol. 24, nr 9, artikel-id 1820
Nyckelord [en]
mesoporous; magnesium carbonate; amine functionalization; cytotoxicity; salicylic acid; drug release
Nationell ämneskategori
Nanoteknik
Identifikatorer
URN: urn:nbn:se:uu:diva-381421DOI: 10.3390/molecules24091820OAI: oai:DiVA.org:uu-381421DiVA, id: diva2:1303564
Tillgänglig från: 2019-04-10 Skapad: 2019-04-10 Senast uppdaterad: 2019-05-13
Ingår i avhandling
1. Development of Nanoporous Inorganic Carbonates for Pharmaceutical and Environmental Applications
Öppna denna publikation i ny flik eller fönster >>Development of Nanoporous Inorganic Carbonates for Pharmaceutical and Environmental Applications
2019 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Mesoporous magnesium carbonate (MMC) is a highly porous, anhydrous material which can be synthesized without the use of templates. This thesis shows how post- and in synthesis modification of MMC can create porous inorganic carbonates suitable for different pharmaceutical and environmental applications. 

Controlled release of IBU was achieved by loading IBU onto amine modified MMC (aMMC). The amine coverage was varied and there was a clear correlation between the release rate of IBU and the amine coverage, the higher the amine coverage the slower the release rate. aMMC was also used to load salicylic acid (SA). SA was then released within 15 minutes in a phosphate buffer (pH 6.8). The cytotoxicity of aMMC was evaluated and it was found non-toxic for human dermal fibroblast cells with particle concentration up to 1000 µg/mL for 48 h of exposure.  aMMC also showed a high adsorption capacity for three different types of anionic azo dyes;  acid red 183, amaranth and reactive black 5. The addition of amine groups to the surface of MMC significantly increased the uptake of the three dyes tested. Composite materials were synthesized by combining the synthesis of MMC and the synthesis of highly porous amorphous calcium carbonate. The calcium magnesium carbonate composite materials were evaluated for their CO2 sorption capacity (at 650 °C) and their CO2 cyclic stability. Addition of Al(NO3)3 to the best performing composite further improved its cyclic stability and the composite maintained a high CO2 uptake over 23 sorption/desorption cycles. Composite materials were also made by adding Al2O3 and SiO2 nanoparticles to the synthesis liquid of MMC.  This resulted in materials with Al2O3 and SiO2 incorporated into the porous MMC structure. The MMC materials with Al2O3 and SiO2 nanoparticles was then impregnated with Ni(NO3)2, calcined and used for catalytic conversion of syngas to natural gas. The material containing Al2O3 nanoparticles performed the best and had a CO conversion of close to 100% at 350°C as well as a high CH4 yield and selectivity.

In this thesis porous inorganic carbonates have been developed and evaluated for their performance in different pharmaceutical and environmental applications.

Ort, förlag, år, upplaga, sidor
Uppsala: Acta Universitatis Upsaliensis, 2019. s. 65
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 1801
Nyckelord
Mesoporous magnesium carbonate, drug delivery, water purification, CO2 capture, catalysis
Nationell ämneskategori
Nanoteknik
Forskningsämne
Teknisk fysik med inriktning mot nanoteknologi och funktionella material
Identifikatorer
urn:nbn:se:uu:diva-381336 (URN)978-91-513-0638-4 (ISBN)
Disputation
2019-06-03, Polhemssalen, Ångströmslaboratoriet, Lägerhyddsvägen 1, Uppsala, 09:30 (Engelska)
Opponent
Handledare
Tillgänglig från: 2019-05-10 Skapad: 2019-04-10 Senast uppdaterad: 2019-06-18

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