uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The fracture predictive ability of a musculoskeletal composite score in old men - data from the MrOs Sweden study
Lund Univ, Skane Univ Hosp, Dept Clin Sci & Orthoped, Clin & Mol Osteoporosis Res Unit, Malmo, Sweden.
Lund Univ, Skane Univ Hosp, Dept Clin Sci & Orthoped, Clin & Mol Osteoporosis Res Unit, Malmo, Sweden.
Lund Univ, Skane Univ Hosp, Dept Clin Sci & Orthoped, Clin & Mol Osteoporosis Res Unit, Malmo, Sweden.
Univ Gothenburg, Sahlgrenska Acad, Ctr Bone & Arthrit Res, Dept Internal Med & Clin Nutr,Inst Med, Gothenburg, Sweden.
Show others and affiliations
2019 (English)In: BMC Geriatrics, ISSN 1471-2318, E-ISSN 1471-2318, Vol. 19, article id 90Article in journal (Refereed) Published
Abstract [en]

Background: Detection of high-risk individuals for fractures are needed. This study assessed whether level of physical activity (PA) and a musculoskeletal composite score could be used as fracture predictive tools, and if the score could predict fractures better than areal bone mineral density (aBMD).

Methods: MrOs Sweden is a prospective population-based observational study that at baseline included 3014 men aged 69-81years. We assessed femoral neck bone mineral content (BMC), bone area, aBMD and total body lean mass by dual energy X-ray absorptiometry, calcaneal speed of sound by quantitative ultrasound and hand grip strength by a handheld dynamometer. PA was assessed by the Physical Activity Scale for the Elderly (PASE) questionnaire. We followed the participants until the date of first fracture, death or relocation (median 9.6years). A musculoskeletal composite score was calculated as mean Z-score of the five measured traits. A Cox proportional hazards model was used to analyze the association between the musculoskeletal traits, the composite score and incident fractures (yes/no) during the follow-up period. Data are presented as hazard ratios (HR) with 95% confidence intervals (95% CI) for fracture for a+1 standard deviation (SD) change (+1 Z-score) in the various musculoskeletal traits as well as the composite score. We used a linear regression model to estimate the association between level of PA, measured as PASE-score and the different musculoskeletal traits as well as the composite score.

Results: A+1 SD higher composite score was associated with an incident fracture HR of 0.61 (0.54, 0.69), however not being superior to aBMD in fracture prediction. A+1 SD higher PASE-score was associated with both a higher composite score and lower fracture incidence (HR 0.83 (0.76, 0.90)).

Conclusions: The composite score was similar to femoral neck aBMD in predicting fractures, and also low PA predicted fractures. This highlights the need of randomized controlled trials to evaluate if PA could be used as a fracture preventive strategy.

Place, publisher, year, edition, pages
BMC , 2019. Vol. 19, article id 90
Keywords [en]
Bone mass, Osteoporosis, Physical activity, Older, Men
National Category
Orthopaedics
Identifiers
URN: urn:nbn:se:uu:diva-381584DOI: 10.1186/s12877-019-1106-2ISI: 000462214300001PubMedID: 30902044OAI: oai:DiVA.org:uu-381584DiVA, id: diva2:1304298
Available from: 2019-04-12 Created: 2019-04-12 Last updated: 2019-04-12Bibliographically approved

Open Access in DiVA

fulltext(565 kB)30 downloads
File information
File name FULLTEXT01.pdfFile size 565 kBChecksum SHA-512
842adbc4c68ff12960a497cb3d784a5330e64acb7b906f454a2088ee8b5ebc010e9a809fdc3a2ec362f8fc589b3d8a5fde622f0f6b39d8f014fc631110e7abea
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Ribom, Eva L

Search in DiVA

By author/editor
Ribom, Eva L
By organisation
Orthopaedics
In the same journal
BMC Geriatrics
Orthopaedics

Search outside of DiVA

GoogleGoogle Scholar
Total: 30 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 59 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf