The time-course of the inflammatory response to major burn injury and its relation to organ failure and outcomeShow others and affiliations
2019 (English)In: Burns, ISSN 0305-4179, E-ISSN 1879-1409, Vol. 45, no 2, p. 354-363Article in journal (Refereed) Published
Abstract [en]
Burn injury causes major inflammatory activation and cytokine release, however, the temporal resolution of the acute and sub-acute inflammatory response has not yet been fully delineated. To this end, we have quantified 20 inflammatory mediators in plasma from 44 adult patients 0-21 days after burn injury and related the time course of these mediators to % total body surface area (TBSA) burned, clinical parameters, organ failure and outcome. Of the cytokines analyzed in these patients, interleukin 6 (IL-6), IL-8, IL-10 and monocyte chemoattractant protein 1 (MCP-1) correlated to the size of the injury at 24-48h after burn injury. In our study, the concentration of IL-10 had prognostic value in patients with burn injury both measured at admission and at 24-48h after injury. However, simple demographic data such as age, % burned TBSA, inhalation injury and their combination, the Baux score and modified Baux score, outperform most of the cytokines, with the exception of IL-8 and MCP1 levels on admission, in predicting death.
Place, publisher, year, edition, pages
ELSEVIER SCI LTD , 2019. Vol. 45, no 2, p. 354-363
Keywords [en]
Cytokines, Burns, Mortality, Multiple organ failure, Severity of illness index
National Category
Anesthesiology and Intensive Care Surgery
Identifiers
URN: urn:nbn:se:uu:diva-380482DOI: 10.1016/j.burns.2018.09.001ISI: 000461044900012PubMedID: 30274808OAI: oai:DiVA.org:uu-380482DiVA, id: diva2:1304999
2019-04-152019-04-152024-02-20Bibliographically approved