Decrease in inflammatory biomarker concentration by intervention with selenium and coenzyme Q10: a subanalysis of osteopontin, osteoprotergerin, TNFr1, TNFr2 and TWEAK
2019 (engelsk)Inngår i: Journal of Inflammation, E-ISSN 1476-9255, Vol. 16, artikkel-id 5Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]
Background:
Inflammation is central to the pathogenesis of many diseases. Supplementation with selenium and coenzyme Q10 has been shown to reduce cardiovascular mortality, and increase cardiac function in elderly persons with a low intake of selenium. There are indications that one of the mechanisms of this positive effect is a decrease in inflammation.
Methods:
Osteopontin, osteoprotegerin, sTNF receptor 1, sTNF receptor 2 and the tumor necrosis factor-like weak inducer of apoptosis called TWEAK, were determined in plasma after 6 months and 42months in 219 community-living elderly persons, of whom 119 received supplements of selenium (200g/day) and coenzyme Q10 (200mg/day), and 101 received a placebo. Repeated measures of variance were used to evaluate the levels, and the results were validated through ANCOVA analyses with adjustments for important covariates.
Results:
Significantly lower concentrations of four of the five biomarkers for inflammation were observed as a result of the intervention with the supplements. Only TWEAK did not show significant differences.
Conclusion:
In this sub-analysis of the intervention with selenium and coenzyme Q10 or placebo in an elderly community-living population, biomarkers for inflammation were evaluated. A significantly lower concentration in four of the five biomarkers tested could be demonstrated as a result of the supplementation, indicating a robust effect on the inflammatory system. The decrease in inflammation could be one of the mechanisms behind the positive clinical results on reduced cardiovascular morbidity and mortality reported earlier as a result of the intervention. The study is small and should be regarded as hypothesis-generating, but nonetheless adds important data about mechanisms presently known to increase the risk of clinical effects such as reduced cardiovascular mortality, increased cardiac function and better health-related quality of life scoring, as previously demonstrated in the active treatment group.
sted, utgiver, år, opplag, sider
2019. Vol. 16, artikkel-id 5
Emneord [en]
Selenium, Coenzyme Q10, Elderly, Inflammation, Intervention
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-381077DOI: 10.1186/s12950-019-0210-6ISI: 000461930800001PubMedID: 30923464OAI: oai:DiVA.org:uu-381077DiVA, id: diva2:1306353
2019-04-232019-04-232023-10-04bibliografisk kontrollert