uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Regulatory changes in pterin and carotenoid genes underlie balanced color polymorphisms in the wall lizard
Univ Porto, CIBIO InBIO, Ctr Invest Biodiversidade & Recursos Genet, P-4485661 Vairao, Portugal;Univ Porto, Dept Biol, Fac Ciencias, P-4169007 Porto, Portugal.
Univ Porto, CIBIO InBIO, Ctr Invest Biodiversidade & Recursos Genet, P-4485661 Vairao, Portugal.
Univ Porto, CIBIO InBIO, Ctr Invest Biodiversidade & Recursos Genet, P-4485661 Vairao, Portugal.
Univ Porto, CIBIO InBIO, Ctr Invest Biodiversidade & Recursos Genet, P-4485661 Vairao, Portugal.ORCID iD: 0000-0001-7212-991X
Show others and affiliations
2019 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 116, no 12, p. 5633-5642Article in journal (Refereed) Published
Abstract [en]

Reptiles use pterin and carotenoid pigments to produce yellow, orange, and red colors. These conspicuous colors serve a diversity of signaling functions, but their molecular basis remains unresolved. Here, we show that the genomes of sympatric color morphs of the European common wall lizard (Podarcis muralis), which differ in orange and yellow pigmentation and in their ecology and behavior, are virtually undifferentiated. Genetic differences are restricted to two small regulatory regions near genes associated with pterin [sepiapterin reductase (SPR)] and carotenoid [beta-carotene oxygenase 2 (BCO2)] metabolism, demonstrating that a core gene in the housekeeping pathway of pterin biosynthesis has been coopted for bright coloration in reptiles and indicating that these loci exert pleiotropic effects on other aspects of physiology. Pigmentation differences are explained by extremely divergent alleles, and haplotype analysis revealed abundant transspecific allele sharing with other lacertids exhibiting color polymorphisms. The evolution of these conspicuous color ornaments is the result of ancient genetic variation and cross-species hybridization.

Place, publisher, year, edition, pages
2019. Vol. 116, no 12, p. 5633-5642
Keywords [en]
Podarcis muralis, carotenoid pigmentation, pterin pigmentation, balanced polymorphism, introgression
National Category
Evolutionary Biology
Identifiers
URN: urn:nbn:se:uu:diva-381075DOI: 10.1073/pnas.1820320116ISI: 000461679000067PubMedID: 30819892OAI: oai:DiVA.org:uu-381075DiVA, id: diva2:1306370
Funder
Knut and Alice Wallenberg FoundationSwedish Research Council, 2017-02907Swedish Research Council, E0446501EU, Horizon 2020, PTDC/BIA-EVL/30288/2017 -NORTE -01-0145-FEDER-30288EU, Horizon 2020, PTDC/BIA-EVL/30288/2017 -NORTE -01-0145-FEDER-30288EU, FP7, Seventh Framework Programme, 286431Swedish Research CouncilAvailable from: 2019-04-23 Created: 2019-04-23 Last updated: 2019-04-23Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Rubin, Carl-JohanWallerman, OlaBunikis, IgnasSoler, LucileAndersson, Leif

Search in DiVA

By author/editor
Afonso, SandraRubin, Carl-JohanWallerman, OlaBunikis, IgnasCarretero, Miguel A.Soler, LucileAndersson, Leif
By organisation
Department of Medical Biochemistry and MicrobiologyScience for Life Laboratory, SciLifeLabDepartment of Immunology, Genetics and Pathology
In the same journal
Proceedings of the National Academy of Sciences of the United States of America
Evolutionary Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 52 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf