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Assessment of the reliability of the motor unit size index (MUSIX) in single subject "round-robin" and multi-centre settings
Univ Sheffield, Sheffield Inst Translat Neurosci, 385A Glossop Rd, Sheffield S10 2HQ, S Yorkshire, England.
Kantonsspital, Neuromuscular Dis Unit ALS Clin, St Gallen, Switzerland.
Univ Sheffield, Stat Serv Unit, Sheffield, S Yorkshire, England.
Kantonsspital, Neuromuscular Dis Unit ALS Clin, St Gallen, Switzerland.
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2019 (English)In: Clinical Neurophysiology, ISSN 1388-2457, E-ISSN 1872-8952, Vol. 130, no 5, p. 666-674Article in journal (Refereed) Published
Abstract [en]

Objective: The motor unit size index (MUSIX) is incorporated into the motor unit number index (MUNIX). Our objective was to assess the intra-/inter-rater reliability of MUSIX in healthy volunteers across single subject "round robin" and multi-centre settings.

Methods: Data were obtained from (i) a round-robin assessment in which 12 raters (6 with prior experience and 6 without) assessed six muscles (abductor pollicis brevis, abductor digiti minimi, biceps brachii, tibialis anterior, extensor digitorum brevis and abductor hallucis) and (ii) a multi-centre study with 6 centres studying the same muscles in 66 healthy volunteers. Intrafinter-rater data were provided by 5 centres, 1 centre provided only intra-rater data. Intrafinter-rater variability was assessed using the coefficient of variation (COV), Bland-Altman plots, bias and 95% limits of agreement.

Results: In the round-robin assessment intra-rater COVs for MUSIX ranged from 7.8% to 28.4%. Inter-rater variability was between 7.8% and 16.2%. Prior experience did not impact on MUSIX values. In the multi-centre study MUSIX was more consistent than the MUNIX. Abductor hallucis was the least reliable muscle.

Conclusions: The MUSIX is a reliable neurophysiological biomarker of reinnervation.

Significance: MUSIX could provide insights into the pathophysiology of a range of neuromuscular disorders, providing a quantitative biomarker of reinnervation.

Place, publisher, year, edition, pages
ELSEVIER IRELAND LTD , 2019. Vol. 130, no 5, p. 666-674
Keywords [en]
Motor unit number index, Motor unit size index, Motor unit, Motor neuron, Amyotrophic lateral sclerosis, Electrophysiology
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-382374DOI: 10.1016/j.clinph.2019.01.020ISI: 000463537100007PubMedID: 30870802OAI: oai:DiVA.org:uu-382374DiVA, id: diva2:1306884
Available from: 2019-04-25 Created: 2019-04-25 Last updated: 2019-04-25Bibliographically approved

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Stålberg, ErikSandberg, Arne

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