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Measurement of sCD27 in the cerebrospinal fluid identifies patients with neuroinflammatory disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Landtblom: Neurology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Geriatrics.ORCID iD: 0000-0001-5466-8370
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden..
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2019 (English)In: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 332, p. 31-36Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Laboratory tests to assist in the diagnosis and monitoring of neuroinflammatory diseases are scarce. The soluble form of the CD27 molecule (sCD27) is shed in high concentrations by activated T cells and can be detected in the cerebrospinal fluid. The aim of this study was to investigate whether CSF quantitation of sCD27 could discriminate between inflammatory and non-inflammatory neurological diseases.

METHODS: The concentration of sCD27 was measured using a commercially available ELISA in 803 well-defined subjects from a study cohort comprised of 338 patients with neuroinflammatory disease, 338 with non-inflammatory neurological disease and 127 controls without neurological disease.

RESULTS: The median value of cerebrospinal fluid sCD27 was 64 pg/mL (IQR 0-200) in controls, 58 pg/mL (IQR 0-130) in patients with non-inflammatory disease and 740 pg/mL (IQR 230-1800) in patients with inflammatory disease. The likelihood ratio of having an inflammatory disease was 10 (sensitivity 74% and specificity 93%) if the sCD27 concentration was >250 pg/mL. In patients with a known inflammatory condition, the likelihood ratio of having an infection was 10 (sensitivity 40% and specificity 96%) if the sCD27 concentration was >2500 pg/mL.

CONCLUSIONS: The likelihood of having an inflammatory neurological condition is increased with elevated concentrations of sCD27 in cerebrospinal fluid. Rapid tests of sCD27 should be developed to assist clinicians in diagnosis of neuroinflammatory disease.

Place, publisher, year, edition, pages
2019. Vol. 332, p. 31-36
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-381319DOI: 10.1016/j.jneuroim.2019.03.015ISI: 000470940600004PubMedID: 30928869OAI: oai:DiVA.org:uu-381319DiVA, id: diva2:1307446
Available from: 2019-04-26 Created: 2019-04-26 Last updated: 2019-07-05Bibliographically approved

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Feresiadou, AmaliaNilsson, KennethIngelsson, MartinNygren, IngelaNiemelä, ValterGordh, TorstenCunningham, JanetKultima, KimLarsson, AndersBurman, Joachim

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Feresiadou, AmaliaNilsson, KennethIngelsson, MartinNygren, IngelaNiemelä, ValterGordh, TorstenCunningham, JanetKultima, KimLarsson, AndersBurman, Joachim
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Landtblom: NeurologyClinical MicrobiologyGeriatricsNeurologyAnaesthesiology and Intensive CarePsychiatry, University HospitalClinical Chemistry
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