uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Attachment Patterns of Human and Avian Influenza Viruses to Trachea and Colon of 26 Bird Species: Support for the Community Concept
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. (Zoonosis Science Center)
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology.ORCID iD: 0000-0001-5611-1015
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. (Zoonosis Science Center)
Linnaeus Univ, Ctr Ecol & Evolut Microbial Model Syst, Kalmar, Sweden.
Show others and affiliations
2019 (English)In: Frontiers in Microbiology, ISSN 1664-302X, E-ISSN 1664-302X, Vol. 10, article id 815Article in journal (Refereed) Published
Abstract [en]

Avian influenza A viruses (AIVs) have a broad host range, but are most intimately associated with waterfowl (Anseriformes) and, in the case of the H13 and H16 subtypes, gulls (Charadriiformes). Host associations are multifactorial, but a key factor is the ability of the virus to bind host cell receptors and thereby initiate infection. The current study aims at investigating the tissue attachment pattern of a panel of AIVs, comprising H3N2, H6N1, H12N5, and H16N3, to avian trachea and colon tissue samples obtained from host species of different orders. Virus attachment was not restricted to the bird species or order from which the virus was isolated. Instead, extensive virus attachment was observed to several distantly related avian species. In general, more virus attachment and receptor expression were observed in trachea than in colon samples. Additionally, a human seasonal H3N2 virus was studied. Unlike the studied AIVs, this virus mainly attached to tracheae from Charadriiformes and a very limited set of avian cola. In conclusion, the reported results highlight the importance of AIV attachment to trachea in many avian species. Finally, the importance of chickens and mallards in AIVs dynamics was illustrated by the abundant AIV attachment observed.

Place, publisher, year, edition, pages
2019. Vol. 10, article id 815
Keywords [en]
virus histochemistry, lectin staining, pattern of virus attachment, avian influenza, birds
National Category
Microbiology
Identifiers
URN: urn:nbn:se:uu:diva-382841DOI: 10.3389/fmicb.2019.00815ISI: 000464963200002PubMedID: 31057520OAI: oai:DiVA.org:uu-382841DiVA, id: diva2:1317235
Funder
Swedish Research Council, 2015-03877Swedish Research Council, 2016-02596Knut and Alice Wallenberg Foundation
Note

De 2 första författarna delar förstaförfattarskapet.

Available from: 2019-05-22 Created: 2019-05-22 Last updated: 2019-10-24Bibliographically approved
In thesis
1.
The record could not be found. The reason may be that the record is no longer available or you may have typed in a wrong id in the address field.

Open Access in DiVA

fulltext(2853 kB)50 downloads
File information
File name FULLTEXT01.pdfFile size 2853 kBChecksum SHA-512
e8dc999ee91f4fba6be34fb2b0cf51bb6ef5ad84daffdc332488695b5802625db1460be84e648912b534a567f58d40b5be49926044b36d23ebc25d1506d2c990
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Eriksson, PerLindskog, CeciliaJärhult, Josef D.Lundkvist, ÅkeOlsen, BjörnEllström, Patrik

Search in DiVA

By author/editor
Eriksson, PerLindskog, CeciliaJärhult, Josef D.Lundkvist, ÅkeOlsen, BjörnEllström, Patrik
By organisation
Department of Medical Biochemistry and MicrobiologyScience for Life Laboratory, SciLifeLabClinical and experimental pathologyInfection medicine
In the same journal
Frontiers in Microbiology
Microbiology

Search outside of DiVA

GoogleGoogle Scholar
Total: 50 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 132 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf