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Framtidens biomarkörer: En prioritering av proteinerna i det humana plasmaproteomet
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
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2019 (Swedish)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

In this report, we rank possible protein biomarkers based on different criteria for use in Olink Proteomics’ protein panels. We started off with a list compiled through the Human Plasma Proteome Project (HPPP) and have in different ways used this to obtain the final results. To complete this task we compared the list with Olink’s and its competitors’ protein catalogs, identified diseases beyond Olink’s coverage and the proteins linked with these. We also created a scoring system used to fa- cilitate detection of good biomarkers. From this, we have concluded that Olink should focus on proteins that the competitors have in their catalogs and proteins that can be found in many pathways and are linked with many diseases. From each of the methods used, we have been able to identify a number of proteins that we recommend Olink to investigate further.

Place, publisher, year, edition, pages
2019. , p. 37
Keywords [sv]
Biomarkör, plasmaproteom
National Category
Bioinformatics (Computational Biology)
Identifiers
URN: urn:nbn:se:uu:diva-384709OAI: oai:DiVA.org:uu-384709DiVA, id: diva2:1321361
External cooperation
Olink Proteomics
Educational program
Molecular Biotechnology Engineering Programme
Supervisors
Examiners
Available from: 2019-06-13 Created: 2019-06-07 Last updated: 2019-06-13Bibliographically approved

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