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Optic nerve head morphometry for glaucoma diagnosis, optimization of clinical measurement strategy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Söderberg: Ophthalmic Biophysics. (Per Söderberg)ORCID iD: 0000-0002-7157-2802
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Söderberg: Ophthalmic Biophysics.ORCID iD: 0000-0003-0654-5856
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Söderberg: Ophthalmic Biophysics. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg.
2019 (English)In: Proceedings of SPIE, ISSN 0277-786X, Vol. 10858, p. 45:1-45:8, article id 108581CArticle in journal (Refereed) Published
Abstract [en]

The present study aimed to develop a strategy for evaluation of instant PIMD-2 pi measurements as a basis for clinical monitoring of glaucoma. PIMD-2 pi is a morphometric measure of the waist of the nerve fiber layer at the optic nerve head (ONH). Clinical measurements of PIMD-2 pi in patients with early to moderate stage glaucoma demonstrated a high variability among subjects. The high variability among subjects renders comparison of instant PIMD-2 pi measurements to tolerance limits for normality derived from a normative database inefficient. It is suggested to instead compare sequential measurements of PIMD-2 pi within a patient. Initially, the difference between an instant measurement and the average of previous measurements can be compared to tolerance limits for difference between measurements within subject. Once, a potential loss of PIMD-2 pi is detected, a sufficient number of measurements within a sufficiently wide time interval can be used to estimate the PIMD-2 pi loss rate with regression and the deviation of the estimated loss rate can be evaluated as a 95 % confidence interval for the loss rate. If the upper confidence limit excludes 0, a significant loss rate has been detected. The currently proposed strategy has the potential to detect glaucoma earlier than the current gold standard, computer perimetry, with less inconvenience for the patient.

Place, publisher, year, edition, pages
2019. Vol. 10858, p. 45:1-45:8, article id 108581C
National Category
Ophthalmology
Identifiers
URN: urn:nbn:se:uu:diva-384735DOI: 10.1117/12.2516319ISI: 000481649100010OAI: oai:DiVA.org:uu-384735DiVA, id: diva2:1321422
Conference
Conference on Ophthalmic Technologies XXIX, SPIE BiOS 2019, San Francisco, California, United States, Feb 2-3, 2019
Available from: 2019-06-07 Created: 2019-06-07 Last updated: 2019-09-27Bibliographically approved

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Söderberg, PerYu, ZhaohuaSandberg Melin, Camilla

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