uu.seUppsala universitets publikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Endocrine paraneoplastic syndromes in patients with neuroendocrine neoplasms
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Endokrinkirurgi. Univ Athens, Laiko Hosp, Dept Propauped Internal Med 1, Oncol Unit, Athens, Greece.
Univ Athens, Laiko Hosp, Dept Propauped Internal Med 1, Oncol Unit, Athens, Greece;251 Hellen Air Force & VA Gen Hosp, Athens, Greece.
Univ Athens, Laiko Hosp, Dept Propauped Internal Med 1, Oncol Unit, Athens, Greece.
Linkoping Univ, Div Endocrinol, Dept Med & Hlth Sci, Linkoping, Sweden.
Vise andre og tillknytning
2019 (engelsk)Inngår i: Endocrine (Basingstoke), ISSN 1355-008X, E-ISSN 1559-0100, Vol. 64, nr 2, s. 384-392Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective: Our aim was to assess the prevalence of endocrine paraneoplastic syndromes (EPNS) in neuroendocrine neoplasms (NENs) and estimate its impact on patient outcomes.

Design: This is a retrospective analysis of 834 patients with NENs (611 gastrointestinal, 166 thoracic, 57 of unknown and various other primary origin). We included 719 consecutive NEN patients treated at EKPA-Laiko Hospital, Athens, Greece and 115 patients with lung carcinoid (LC) treated at Uppsala University Hospital, Uppsala, Sweden. EPNS diagnosis was based on standard criteria.

Methods: Twenty-one patients with EPNS were detected: 16 with ectopic Cushing's syndrome (ECS), one with hypercalcaemia due to parathyroid hormone-related protein (PTHrP) secretion, three with hypercalcitonaemia and one patient with dual secretion of calcitonin and beta-human chorionic gonadotropin (-HCG). All tumours were well-differentiated; 10 patients had Stage IV disease at diagnosis.

Results: The prevalence of EPNS in the Greek cohort was 1.9%, whereas that of ECS among LC patients in both centres was 6.7%. Median overall survival (OS) for patients with EPNS was 160.7 months (95%CI, 86-235.4) and median event-free survival (EFS) was 25.9 months (95%CI, 0-57.2). Patients presenting with EPNS prior to NEN diagnosis had longer EFS compared to patients with synchronous or metachronous EPNS (log-rank P=0.013). Patients with ECS of extra-thoracic origin demonstrated shorter OS and EFS compared to patients with ECS of lung or thymic origin (log-rank P=0.001 and P<0.001, respectively). LC patients with and without ECS were comparable in 5-year and 10-year OS rates (66.7% and 33.3% versus 89.8% and 60.2%, respectively; 95%CI [189.6-300.4 months], log-rank P=0.94) and in median EFS, 67 versus 183 months, 95%CI [50.5-207.5], log-rank P=0.12).

Conclusion: EPNS are relatively rare in patients with NENs and mainly concern well-differentiated tumours of the foregut. Among patients with EPNS, LC-related ECS may not adversely affect patient outcomes when diagnosed prior to NEN and effectively been treated.

sted, utgiver, år, opplag, sider
SPRINGER , 2019. Vol. 64, nr 2, s. 384-392
Emneord [en]
Paraneoplastic syndrome, Neuroendocrine tumours, Ectopic Cushing's syndrome, Hypercalcitonaemia, PTHrP secretion
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-386165DOI: 10.1007/s12020-018-1773-3ISI: 000468840200021PubMedID: 30280284OAI: oai:DiVA.org:uu-386165DiVA, id: diva2:1327989
Merknad

De två första författarna delar förstaförfattarskapet.

Tilgjengelig fra: 2019-06-20 Laget: 2019-06-20 Sist oppdatert: 2019-06-20bibliografisk kontrollert

Open Access i DiVA

fulltext(1061 kB)60 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 1061 kBChecksum SHA-512
6c71c93c73185ad4f48c58c77d4f0fe8187be3de0c59d7ca0a6ecb310fb41dda92612afb9afb6b99773a66bd58653b0f18b19c27a418a8cab0db1f6b27793580
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Daskalakis, KosmasTsolakis, Apostolos V.

Søk i DiVA

Av forfatter/redaktør
Daskalakis, KosmasDimitriadis, Georgios K.Tsolakis, Apostolos V.
Av organisasjonen
I samme tidsskrift
Endocrine (Basingstoke)

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 60 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 130 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf