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Regulatory Immune Mechanisms beyond Regulatory T Cells
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrative Physiology.
La Jolla Inst Allergy & Immunol, Type Diabet Ctr 1, La Jolla, CA 92037 USA;Novo Nordisk Res Ctr, Seattle, WA 98109 USA.
2019 (English)In: Trends in immunology, ISSN 1471-4906, E-ISSN 1471-4981, Vol. 40, no 6, p. 482-491Article, review/survey (Refereed) Published
Abstract [en]

In autoimmunity, aggressive immune responses are counteracted by suppressive rejoinders. For instance, FOXP3-expressing regulatory T cells (Tregs), have shown remarkable effects in limiting autoimmunity in preclinical models. However, early results from human Treg trials have not been as positive. Here, we highlight questions surrounding Treg transfers as putative treatments for autoimmunity. We discuss whether lack of antigenic recognition might be key to shifting cells from contributing to an aggressive autoresponse, to being part of a regulatory network. Moreover, we argue that identifying the physiological range of immunosuppression of Tregs might help potentiate their efficacy. We propose widening the view on immunoregulation by considering the participation of CD8(+) Tregs in this process, which could have major implications in autoimmunity.

Place, publisher, year, edition, pages
2019. Vol. 40, no 6, p. 482-491
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:uu:diva-387529DOI: 10.1016/j.it.2019.04.005ISI: 000469353000006PubMedID: 31101537OAI: oai:DiVA.org:uu-387529DiVA, id: diva2:1329405
Funder
Swedish Research CouncilSwedish Society for Medical Research (SSMF)Available from: 2019-06-24 Created: 2019-06-24 Last updated: 2019-06-24Bibliographically approved

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