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Postoperative pain and bleeding after adenotonsillectomy versus adenotonsillotomy in pediatric obstructive sleep apnea an RCT
Karolinska Inst, Dept Clin Sci Intervent & Technol, CLINTEC, Stockholm, Sweden.
Karolinska Univ Hosp, Karolinska Inst, Dept Otorhinolaryngol, CLINTEC, Stockholm, Sweden.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.ORCID-id: 0000-0001-8327-1292
2019 (engelsk)Inngår i: European Archives of Oto-Rhino-Laryngology, ISSN 0937-4477, E-ISSN 1434-4726, Vol. 276, nr 11, s. 3231-3238Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

PURPOSE: Our previous randomized controlled trial (RCT) of children with obstructive sleep apnea (OSA) showed no significant differences between adenotonsillectomy (ATE) and adenotonsillomy (ATE) in improving nocturnal respiration and symptoms after one year. This is the continuous report with the evaluation of postoperative morbidity concerning bleeding and pain.

METHODS: A double-blinded RCT including 79 children, aged 2-6 years, with moderate to severe OSA, randomized to either ATE (n = 40) or ATT (n = 39). From one to ten days postoperatively, parents filled in a logbook with six pain-related outcomes (parent and child grading pain at different levels, days of analgesic use and return to normal diet). Peri- and postoperative bleeding were also registered.

RESULTS: 63 patients (80%) returned the logbook. There were significant differences between groups in only two of the six pain-related outcomes in favor of the ATT group; first day when the children graded themselves as pain free (p = 0.021, Log Rank Test), and first day the caregiver estimated pain VAS ≤ 5 (p = 0.007, Log Rank Test). Two (5%) cases of postoperative bleeding occurred in the ATE group, one of which needed a return to theatre. No case of postoperative bleeding was seen in the ATT group.

CONCLUSIONS: The results from this RCT are in line with previous comparative studies between ATT and ATE. Children operated with ATT had significantly less postoperative pain in one-third of the outcomes, and less bleeding than ATE. However, as the differences in morbidity between the surgical methods were minor the clinical significance is uncertain.

TRIAL REGISTRATION: This study was approved by the Swedish Regional Ethics Board in Stockholm, Sweden (Dnr 2011/925-32 and 2013/2274-32) and registered at ClinicalTrials.gov (Trial registration number NCT01676181).

sted, utgiver, år, opplag, sider
2019. Vol. 276, nr 11, s. 3231-3238
Emneord [en]
Adenotonsillectomy, Adenotonsillotomy, Paediatric obstructive sleep apnea, Tonsillectomy, Tonsillotomy
HSV kategori
Forskningsprogram
Oto-rhino-laryngologi
Identifikatorer
URN: urn:nbn:se:uu:diva-390402DOI: 10.1007/s00405-019-05571-wISI: 000492037800035PubMedID: 31377901OAI: oai:DiVA.org:uu-390402DiVA, id: diva2:1341670
Tilgjengelig fra: 2019-08-09 Laget: 2019-08-09 Sist oppdatert: 2019-12-18bibliografisk kontrollert

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