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Serum retinol-binding protein 4 levels in polycystic ovary syndrome
Univ Oulu, Med Res Ctr, PEDEGO Res Unit, Dept Obstet & Gynaecol, Oulu, Finland;Oulu Univ Hosp, Oulu, Finland.
Univ Oulu, Med Res Ctr, PEDEGO Res Unit, Dept Obstet & Gynaecol, Oulu, Finland;Oulu Univ Hosp, Oulu, Finland.
Univ Oulu, Med Res Ctr, PEDEGO Res Unit, Dept Obstet & Gynaecol, Oulu, Finland;Oulu Univ Hosp, Oulu, Finland.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Reproductive Health.ORCID iD: 0000-0002-2491-2042
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2019 (English)In: Endocrine Connections, ISSN 2049-3614, E-ISSN 2049-3614, Vol. 8, no 6, p. 709-717Article in journal (Refereed) Published
Abstract [en]

Objective: Serum levels of retinol-binding protein 4 (RBP4), an adipokine thought to affect systemic insulin sensitivity, were compared between women with polycystic ovary syndrome (PCOS) and non-PCOS controls to evaluate the association of RBP4 with clinical, hormonal and metabolic parameters of PCOS. Subjects and methods: Serum RBP4 levels were analysed in 278 women with PCOS (age range 18-57 years) and 191 non-PCOS controls (age 20-53 years) by enzyme-linked immunosorbent assay. Results: Serum levels of RBP4 were increased in women with PCOS compared with control women in the whole population (45.1 +/- 24.0 (S.D.) vs 33.5 +/- 18.3 mg/L, P < 0.001). Age-stratified analysis showed that serum RBP4 levels were increased in women with PCOS aged <= 30 years compared with controls (47.7 +/- 23.5 vs 27.1 +/- 10.4 mg/L, P < 0.001), whereas no significant differences were seen in the other age groups. No significant correlations of RBP4 were seen with either steroids or indices of insulin resistance. Conclusions: Although serum RBP4 levels were increased in younger women with PCOS compared with age-matched non-PCOS controls, RBP4 does not seem to be a good marker of insulin resistance or other metabolic derangements in women with PCOS.

Place, publisher, year, edition, pages
Bioscientifica, 2019. Vol. 8, no 6, p. 709-717
Keywords [en]
polycystic ovary syndrome (PCOS), retinol-binding protein 4 (RBP4), adipokines
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:uu:diva-390600DOI: 10.1530/EC-19-0116ISI: 000472586000011PubMedID: 31051472OAI: oai:DiVA.org:uu-390600DiVA, id: diva2:1342303
Available from: 2019-08-13 Created: 2019-08-13 Last updated: 2019-08-13Bibliographically approved

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Sundström Poromaa, Inger

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