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Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome-A SYSDIET Sub-Study
Oslo Metropolitan Univ, Fac Hlth Sci, Dept Nursing & Hlth Promot, N-0130 Oslo, Norway.
Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70211, Finland.
Karolinska Inst, Dept Med H7, S-14186 Stockholm, Sweden.
Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70211, Finland.
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2019 (English)In: Molecular Nutrition & Food Research, ISSN 1613-4125, E-ISSN 1613-4133, Vol. 63, no 13, article id 1801405Article in journal (Refereed) Published
Abstract [en]

Scope To explore the effect of a healthy Nordic diet on the global transcriptome profile in peripheral blood mononuclear cells (PBMCs) of subjects with metabolic syndrome. Methods and results Subjects with metabolic syndrome undergo a 18/24 week randomized intervention study comparing an isocaloric healthy Nordic diet with an average habitual Nordic diet served as control (SYSDIET study). Altogether, 68 participants are included. PBMCs are obtained before and after intervention and total RNA is subjected to global transcriptome analysis. 1302 probe sets are differentially expressed between the diet groups (p-value < 0.05). Twenty-five of these are significantly regulated (FDR q-value < 0.25) and are mainly involved in mitochondrial function, cell growth, and cell adhesion. The list of 1302 regulated probe sets is subjected to functional analyses. Pathways and processes involved in the mitochondrial electron transport chain, immune response, and cell cycle are downregulated in the healthy Nordic diet group. In addition, gene transcripts with common motifs for 42 transcription factors, including NFR1, NFR2, and NF-kappa B, are downregulated in the healthy Nordic diet group. Conclusion These results suggest that benefits of a healthy diet may be mediated by improved mitochondrial function and reduced inflammation.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019. Vol. 63, no 13, article id 1801405
Keywords [en]
gene-expression, healthy Nordic diet, metabolic syndrome, peripheral blood mononuclear cells, transcriptome
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:uu:diva-390915DOI: 10.1002/mnfr.201801405ISI: 000473667000001PubMedID: 30964598OAI: oai:DiVA.org:uu-390915DiVA, id: diva2:1343209
Funder
Swedish Research CouncilSwedish Heart Lung FoundationNordForsk, 070014Swedish Diabetes AssociationAvailable from: 2019-08-15 Created: 2019-08-15 Last updated: 2019-08-15Bibliographically approved

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Rosqvist, FredrikRisérus, Ulf

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