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A Low Ankle-Brachial Index and High Brachial-Ankle Pulse Wave Velocity Are Associated with Poor Cognitive Function in Patients Undergoing Hemodialysis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Endocrinology and mineral metabolism. Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung, Taiwan.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung, Taiwan.
Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung, Taiwan;Kaohsiung Med Univ, Kaohsiung Municipal Hsiao Kang Hosp, Dept Internal Med, Kaohsiung, Taiwan.
Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan;Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung, Taiwan;Kaohsiung Med Univ, Kaohsiung Municipal Hsiao Kang Hosp, Dept Internal Med, Kaohsiung, Taiwan.
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2019 (English)In: Disease Markers, ISSN 0278-0240, E-ISSN 1875-8630, Vol. 2019, article id 9421352Article in journal (Refereed) Published
Abstract [en]

Patients with end-stage renal disease (ESRD) have an increased risk of both impaired cognitive function and peripheral artery disease (PAD) than the general population. The association between PAD and dementia is recognized, but there are limited studies in patients with ESRD. The aim of this study was to evaluate the relationship between ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) and cognitive impairment in patients receiving hemodialysis (HD). We enrolled 136 prevalent HD patients (mean age 59.3 +/- 10.5 years, 55.9% male). Cognitive performance was measured using the Montreal Cognitive Assessment (MoCA) and Cognitive Abilities Screening Instrument (CASI) by trained psychiatrists. Associations between the cognitive function and ABI and baPWV were assessed using multiple linear regression analysis. Compared with HD patients with ABI >= 0.9, patients with ABI<0.9 had lower MoCA score (p=0.027) and lower CASI score but did not achieve significant level (p=0.056). In the multivariate stepwise linear regression analysis, ABI (per 0.1) was independently positively associated with the MoCA score (beta coefficient=0.62, p=0.011) and the CASI score (beta coefficient=1.43, p=0.026). There is a negative association between baPWV (per 100cm/s) and CASI (beta coefficient=-0.70, p=0.009). In conclusion, a low ABI or high baPWV was associated with a lower cognitive function in HD patients.

Place, publisher, year, edition, pages
2019. Vol. 2019, article id 9421352
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Endocrinology and Diabetes
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URN: urn:nbn:se:uu:diva-394270DOI: 10.1155/2019/9421352ISI: 000484834000001OAI: oai:DiVA.org:uu-394270DiVA, id: diva2:1359394
Available from: 2019-10-09 Created: 2019-10-09 Last updated: 2019-10-09Bibliographically approved

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Wu, Ping-HsunYi-Ting, Lin

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