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Novel Y-Chromosome Long Non-Coding RNAs Expressed in Human Male CNS During Early Development
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för organismbiologi, Evolution och utvecklingsbiologi.
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2019 (engelsk)Inngår i: Frontiers in Genetics, ISSN 1664-8021, E-ISSN 1664-8021, Vol. 10, artikkel-id 891Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Global microarray gene expression analyses previously demonstrated differences in female and male embryos during neurodevelopment. In particular, before sexual maturation of the gonads, the differences seem to concentrate on the expression of genes encoded on the X- and Y-chromosomes. To investigate genome-wide differences in expression during this early developmental window, we combined high-resolution RNA sequencing with qPCR to analyze brain samples from human embryos during the first trimester of development. Our analysis was tailored for maximum sensitivity to discover Y-chromosome gene expression, but at the same time, it was underpowered to detect X-inactivation escapees. Using this approach, we found that 5 out of 13 expressed game to log pairs showed unbalanced gene dosage, and as a consequence, a male-biased expression. In addition, we found six novel non-annotated long non-coding RNAs on the Y-chromosome with conserved expression patterns in newborn chimpanzee. The tissue specific and time-restricted expression of these long non-coding RNAs strongly suggests important functions during central nervous system development in human males.

sted, utgiver, år, opplag, sider
2019. Vol. 10, artikkel-id 891
Emneord [en]
sex differences, gene expression, X-chromosome, Y-chromosome, long non-coding RNA, RNA sequencing, human brain development, Pan troglodytes
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Identifikatorer
URN: urn:nbn:se:uu:diva-395797DOI: 10.3389/fgene.2019.00891ISI: 000487628500001OAI: oai:DiVA.org:uu-395797DiVA, id: diva2:1365678
Forskningsfinansiär
Swedish Research Council, K2012-61X-22089-01-3EU, European Research Council, 282330Tilgjengelig fra: 2019-10-25 Laget: 2019-10-25 Sist oppdatert: 2019-10-25bibliografisk kontrollert

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Johansson, MartinPottmeier, PhilippZaghlool, AmmarHalvardson, JonatanDarj, ElisabethFeuk, LarsPeuckert, ChristianeJazin, Elena

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