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No association between coffee consumption and risk of atrial fibrillation: A Mendelian randomization study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Nobelsvag 13, S-17177 Stockholm, Sweden.ORCID iD: 0000-0001-5055-5627
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics. Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Nobelsvag 13, S-17177 Stockholm, Sweden.ORCID iD: 0000-0003-0118-0341
2019 (English)In: NMCD. Nutrition Metabolism and Cardiovascular Diseases, ISSN 0939-4753, E-ISSN 1590-3729, Vol. 29, no 11, p. 1185-1188Article in journal (Refereed) Published
Abstract [en]

Background and aims: Some observational studies have found that habitual coffee and caffeine consumption might reduce the risk of atrial fibrillation (AF). We conducted a two-sample Mendelian randomization study to explore the potential association between coffee consumption and AF.

Methods and results: This study was based on summary-level data from the Atrial Fibrillation Consortium, including 588 190 individuals (65 446 cases and 522 744 non-cases). Nine single-nucleotide polymorphisms associated with coffee consumption at significance level of P < 5 x 10(-8) were used as instrumental variables and were obtained from a genome-wide association study that included up to 375 833 individuals. The odds ratio of AF per genetically-predicted 50% increase of coffee consumption was 0.98 (95% confidence interval, 0.88, 1.10; P = 0.80) in the standard inverse-variance weighted analysis. Results were consistent in sensitivity analyses using the weighted median and MR-Egger methods, and no directional pleiotropy (P = 0.37) was observed. Moreover, complementary analyses that separated the coffee-related single-nucleotide polymorphisms based on their association with blood levels of caffeine metabolites (lower, higher, unrelated or unknown association) revealed no association with AF.

Conclusions: This study does not support a causal association between habitual coffee consumption and risk of AF. 

Place, publisher, year, edition, pages
ELSEVIER SCI LTD , 2019. Vol. 29, no 11, p. 1185-1188
Keywords [en]
Atrial fibrillation, Coffee consumption, Mendelian randomization
National Category
Cardiac and Cardiovascular Systems Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:uu:diva-396954DOI: 10.1016/j.numecd.2019.07.015ISI: 000492146700005PubMedID: 31558414OAI: oai:DiVA.org:uu-396954DiVA, id: diva2:1370559
Funder
Swedish Research CouncilAvailable from: 2019-11-15 Created: 2019-11-15 Last updated: 2019-11-15Bibliographically approved

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Larsson, Susanna C.

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