uu.seUppsala universitets publikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Genetic regulation of gene expression and splicing during a 10-year period of human aging
Stanford Univ, Dept Pathol, Sch Med, Stanford, CA USA.
Stanford Univ, Dept Genet, Sch Med, Stanford, CA USA.
Stanford Univ, Dept Genet, Sch Med, Stanford, CA USA.
Stanford Univ, Dept Genet, Sch Med, Stanford, CA USA.
Vise andre og tillknytning
2019 (engelsk)Inngår i: Genome Biology, ISSN 1465-6906, E-ISSN 1474-760X, Vol. 20, nr 1, artikkel-id 230Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Molecular and cellular changes are intrinsic to aging and age-related diseases. Prior cross-sectional studies have investigated the combined effects of age and genetics on gene expression and alternative splicing; however, there has been no long-term, longitudinal characterization of these molecular changes, especially in older age.

Results: We perform RNA sequencing in whole blood from the same individuals at ages 70 and 80 to quantify how gene expression, alternative splicing, and their genetic regulation are altered during this 10-year period of advanced aging at a population and individual level. We observe that individuals are more similar to their own expression profiles later in life than profiles of other individuals their own age. We identify 1291 and 294 genes differentially expressed and alternatively spliced with age, as well as 529 genes with outlying individual trajectories. Further, we observe a strong correlation of genetic effects on expression and splicing between the two ages, with a small subset of tested genes showing a reduction in genetic associations with expression and splicing in older age.

Conclusions: These findings demonstrate that, although the transcriptome and its genetic regulation is mostly stable late in life, a small subset of genes is dynamic and is characterized by a reduction in genetic regulation, most likely due to increasing environmental variance with age.

sted, utgiver, år, opplag, sider
2019. Vol. 20, nr 1, artikkel-id 230
Emneord [en]
Aging, Longevity, Gene expression, Alternative splicing, Gene regulation
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-397638DOI: 10.1186/s13059-019-1840-yISI: 000494710200001PubMedID: 31684996OAI: oai:DiVA.org:uu-397638DiVA, id: diva2:1372279
Tilgjengelig fra: 2019-11-22 Laget: 2019-11-22 Sist oppdatert: 2019-11-22bibliografisk kontrollert

Open Access i DiVA

fulltekst(12593 kB)23 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 12593 kBChecksum SHA-512
72bef809a97ed55c83e12913c3e9fefde998e87174ae7ae89bcff42f60cdd54f7b12f2cdf0c0fb99e329f7e64874ade961b97e9d79622b7e442ee38db1888470
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Cook, Naomi L.Lind, Lars

Søk i DiVA

Av forfatter/redaktør
Cook, Naomi L.Lind, Lars
Av organisasjonen
I samme tidsskrift
Genome Biology

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 23 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 71 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf