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First Aldol Cross-Linked Hyaluronic Acid Hydrogel: Fast and Hydrolytically Stable Hydrogel with Tissue Adhesive Properties
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Polymerkemi.
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Polymerkemi.
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad mekanik.ORCID-id: 0000-0002-0491-1077
Tampere Univ, Bioengn & Nanomed Lab, Fac Med & Hlth Technol, Korkeakoulunkatu 3, Tampere 33720, Finland;Tampere Univ, BioMediTech Inst, Korkeakoulunkatu 3, Tampere 33720, Finland.ORCID-id: 0000-0003-2768-0133
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2019 (engelsk)Inngår i: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 11, nr 41, s. 38232-38239Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Currently, there are limited approaches to tailor 3D scaffolds cross-linked with a stable covalent C-C bond that does not require any catalysts or initiators. We present here the first hydrogels employing aldol condensation chemistry that exhibit exceptional physicochemical properties. We investigated the aldol-cross-linking chemistry using two types of aldehyde-modified hyaluronic acid (HA) derivatives, namely, an enolizable HA-aldehyde (HA-EaI) and a non-enolizable HA-aldehyde (HA-NaI). Hydrogels formed using HA-EaI demonstrate inferior cross linking efficiency (due to intramolecular loop formation), when compared with hydrogels formed by mixing HA-EaI and HA-NaI leading to a cross-aldol product. The change in mechanical properties as a result of cross-linking at different pH values is determined using rheological measurements and is interpreted in terms of molecular weight between cross-links (Me). The novel HA cross-aldol hydrogel demonstrate excellent hydrolytic stability and favorable mechanical properties but allow hyaluronidase-mediated enzymatic degradation. Interestingly, residual aldehyde functionality within the aldol product rendered the tissue adhesive properties by bonding two bone tissues. The aldehyde functionality also facilitated facile post-synthetic modifications with nucleophilic reagents. Finally, we demonstrate that the novel hydrogel is biocompatible with encapsulated stem cells that show a linear rate of expansion in our 3-6 days of study.

sted, utgiver, år, opplag, sider
2019. Vol. 11, nr 41, s. 38232-38239
Emneord [en]
hyaluronic acid, hydrogel, aldol chemistry, tissue adhesive, biomaterial
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Identifikatorer
URN: urn:nbn:se:uu:diva-397131DOI: 10.1021/acsami.9b10239ISI: 000491219700090PubMedID: 31550878OAI: oai:DiVA.org:uu-397131DiVA, id: diva2:1374051
Forskningsfinansiär
EU, FP7, Seventh Framework Programme, FP7/2007-2013/607868EU, FP7, Seventh Framework Programme, 607868Swedish Foundation for Strategic Research , SBE13-0028Swedish Foundation for Strategic Research , StemTherapy 2009-1035Tilgjengelig fra: 2019-11-28 Laget: 2019-11-28 Sist oppdatert: 2019-11-28bibliografisk kontrollert

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Bermejo-Velasco, DanielKadekar, SandeepTavares da Costa, Marcus ViniciusGamstedt, E. KristoferHilborn, JönsVarghese, Oommen P.

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Bermejo-Velasco, DanielKadekar, SandeepTavares da Costa, Marcus ViniciusOommen, Oommen P.Gamstedt, E. KristoferHilborn, JönsVarghese, Oommen P.
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