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Longitudinal cognitive decline in autosomal-dominant Alzheimer's disease varies with mutations in APP and PSEN1 genes
Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, SE-14157 Stockholm, Sweden.
Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, SE-14157 Stockholm, Sweden.
Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Neurogeriatr, Stockholm, Sweden.
Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, SE-14157 Stockholm, Sweden.
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2019 (Engelska)Ingår i: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 82, s. 40-47Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The purpose was to compare longitudinal cognitive changes in APP and PSEN1 gene mutation carriers and noncarriers from four autosomal-dominant Alzheimer's disease (ADAD) families across preclinical and early clinical stages of disease. Carriers (n = 34) with four different mutations (PSEN1(M146V), PSEN1(H163Y), APP(SWE), and APP(ARC)) and noncarriers (n = 41) were followed up longitudinally with repeated cognitive assessments starting many years before the expected clinical onset. The relationship between cognition and years to expected clinical onset, education, age, and type of mutation was analyzed using mixed-effects models. Results showed an education-dependent and time-related cognitive decline with linear and quadratic predictors in mutation carriers. Cognitive decline began close to the expected clinical onset and was relatively rapid afterward in PSEN1 mutation carriers, whereas decline was slower and started earlier than 10 years before expected clinical onset in APP mutation carriers. In noncarriers, the decline was minimal across time in accordance with normal aging. These results suggest that phenotypes for onset and rate of cognitive decline vary with PSEN1 and APP genes, suggesting a behavioral heterogeneity in ADAD. (C) 2019 Elsevier Inc. All rights reserved.

Ort, förlag, år, upplaga, sidor
ELSEVIER SCIENCE INC , 2019. Vol. 82, s. 40-47
Nyckelord [en]
APP, PSEN1, Autosomal dominant, Alzheimer's disease, Cognition, Longitudinal
Nationell ämneskategori
Geriatrik Medicinsk genetik
Identifikatorer
URN: urn:nbn:se:uu:diva-397303DOI: 10.1016/j.neurobiolaging.2019.06.010ISI: 000492678700005PubMedID: 31386938OAI: oai:DiVA.org:uu-397303DiVA, id: diva2:1375910
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VetenskapsrådetTillgänglig från: 2019-12-06 Skapad: 2019-12-06 Senast uppdaterad: 2019-12-06Bibliografiskt granskad

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