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Interferon pathway in SLE: one key to unlocking the mystery of the disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Rheumatology.ORCID iD: 0000-0002-6275-7282
2019 (English)In: Lupus Science and Medicine, ISSN 2053-8790, E-ISSN 1625-9823, Vol. 6, no 1, article id e000270Article, review/survey (Refereed) Published
Abstract [en]

SLE is characterised by an activation of the interferon (IFN) system, which leads to an increased expression of IFN-regulated genes. The reasons behind the IFN signature in SLE are (1) the existence of endogenous IFN inducers, (2) activation of several IFN-producing cell types, (3) production of many different IFNs, (4) a genetic setup promoting IFN production and (5) deficient negative feedback mechanisms. The consequences for the immune system is a continuous stimulation to an immune response, and for the patient a number of different organ manifestations leading to typical symptoms for SLE. In the current review, we will present the existing knowledge of the IFN system and pathway activation in SLE. We will also discuss how this information can contribute to our understanding of both the aetiopathogenesis and some organ manifestations of the disease. We will put forward some issues that are unresolved and should be clarified in order to make a proper stratification of patients with SLE, which seems important when selecting a therapy aiming to downregulate the IFN system.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2019. Vol. 6, no 1, article id e000270
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:uu:diva-401914DOI: 10.1136/lupus-2018-000270ISI: 000494644200001PubMedID: 31497305OAI: oai:DiVA.org:uu-401914DiVA, id: diva2:1385164
Funder
Swedish Research CouncilSwedish Rheumatism AssociationKing Gustaf V Jubilee FundSwedish Society of MedicineAvailable from: 2020-01-13 Created: 2020-01-13 Last updated: 2020-01-13Bibliographically approved

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Rönnblom, LarsLeonard, Dag

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