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Recent Advances in Kaempferia Phytochemistry and Biological Activity: A Comprehensive Review
Tokushima Bunri Univ, Fac Pharmaceut Sci, Tokushima 7708514, Japan;Natl Res Ctr, Chem Nat Cpds Dept, 33 el Bohouth St, Giza 12622, Egypt.ORCID-id: 0000-0003-3302-3623
Natl Res Ctr, Chem Med Plants Dept, 33 El Bohouth St, Giza 12622, Egypt.ORCID-id: 0000-0003-1639-3518
Natl Res Ctr, Chem Nat Cpds Dept, 33 el Bohouth St, Giza 12622, Egypt.
Mansoura Univ, Dept Bot, Fac Sci, Mansoura 35516, Egypt;King Saud Univ, Plant Prod Dept, Coll Food Agr Sci, Riyadh 11451, Saudi Arabia.
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2019 (Engelska)Ingår i: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 11, nr 10, artikel-id 2396Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

Background: Plants belonging to the genus Kaempferia (family: Zingiberaceae) are distributed in Asia, especially in the southeast region, and Thailand. They have been widely used in traditional medicines to cure metabolic disorders, inflammation, urinary tract infections, fevers, coughs, hypertension, erectile dysfunction, abdominal and gastrointestinal ailments, asthma, wounds, rheumatism, epilepsy, and skin diseases.

Objective: Herein, we reported a comprehensive review, including the traditional applications, biological and pharmacological advances, and phytochemical constituents of Kaempheria species from 1972 up to early 2019.

Materials and methods: All the information and reported studies concerning Kaempheria plants were summarized from library and digital databases (e.g., Google Scholar, Sci-finder, PubMed, Springer, Elsevier, MDPI, Web of Science, etc.). The correlation between the Kaempheria species was evaluated via principal component analysis (PCA) and agglomerative hierarchical clustering (AHC), based on the main chemical classes of compounds.

Results: Approximately 141 chemical constituents have been isolated and reported from Kaempferia species, such as isopimarane, abietane, labdane and clerodane diterpenoids, flavonoids, phenolic acids, phenyl-heptanoids, curcuminoids, tetrahydropyrano-phenolic, and steroids. A probable biosynthesis pathway for the isopimaradiene skeleton is illustrated. In addition, 15 main documented components of volatile oils of Kaempheria were summarized. Biological activities including anticancer, anti-inflammatory, antimicrobial, anticholinesterase, antioxidant, anti-obesity-induced dermatopathy, wound healing, neuroprotective, anti-allergenic, and anti-nociceptive were demonstrated.

Conclusions: Up to date, significant advances in phytochemical and pharmacological studies of different Kaempheria species have been witnessed. So, the traditional uses of these plants have been clarified via modern in vitro and in vivo biological studies. In addition, these traditional uses and reported biological results could be correlated via the chemical characterization of these plants. All these data will support the biologists in the elucidation of the biological mechanisms of these plants.

Ort, förlag, år, upplaga, sidor
MDPI , 2019. Vol. 11, nr 10, artikel-id 2396
Nyckelord [en]
Kaempferia, traditional medicine, diterpenoids, flavonoids, phenolic, biosynthesis
Nationell ämneskategori
Botanik
Identifikatorer
URN: urn:nbn:se:uu:diva-403539DOI: 10.3390/nu11102396ISI: 000498227300137PubMedID: 31591364OAI: oai:DiVA.org:uu-403539DiVA, id: diva2:1389479
Tillgänglig från: 2020-01-30 Skapad: 2020-01-30 Senast uppdaterad: 2020-01-30Bibliografiskt granskad

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Elshamy, Abdelsamed I.Mohamed, Tarik A.Shahat, Abdelaaty A.El-Seedi, Hesham
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