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Anabolic androgenic steroids exert a selective remodeling of the plasma lipidome that mirrors the decrease of the de novo lipogenesis in the liver
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Analytical Pharmaceutical Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
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2020 (English)In: Metabolomics, ISSN 1573-3882, E-ISSN 1573-3890, Vol. 16, no 1, article id 12Article in journal (Refereed) Published
Abstract [en]

Introduction: The abuse of anabolic androgenic steroids (AASs) is a source of public concern because of their adverse effects. Supratherapeutic doses of AASs are known to be hepatotoxic and regulate the lipoproteins in plasma by modifying the metabolism of lipids in the liver, which is associated with metabolic diseases. However, the effect of AASs on the profile of lipids in plasma is unknown.

Objectives: To describe the changes in the plasma lipidome exerted by AASs and to discuss these changes in the light of previous research about AASs and de novo lipogenesis in the liver.

Methods: We treated male Wistar rats with supratherapeutic doses of nandrolone decanoate and testosterone undecanoate. Subsequently, we isolated the blood plasma and performed lipidomics analysis by liquid chromatography-high resolution mass spectrometry.

Results: Lipid profiling revealed a decrease of sphingolipids and glycerolipids with palmitic, palmitoleic, stearic, and oleic acids. In addition, lipid profiling revealed an increase in free fatty acids and glycerophospholipids with odd-numbered chain fatty acids and/or arachidonic acid.

Conclusion: The lipid profile presented herein reports the imprint of AASs on the plasma lipidome, which mirrors the downregulation of de novo lipogenesis in the liver. In a broader perspective, this profile will help to understand the influence of androgens on the lipid metabolism in future studies of diseases with dysregulated lipogenesis (e.g. type 2 diabetes, fatty liver disease, and hepatocellular carcinoma).

Place, publisher, year, edition, pages
SPRINGER , 2020. Vol. 16, no 1, article id 12
Keywords [en]
Androgens, Androgen receptor, Estrogen receptors, Lipidomics, Liver X receptors
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-407500DOI: 10.1007/s11306-019-1632-0ISI: 000516536100002PubMedID: 31925559OAI: oai:DiVA.org:uu-407500DiVA, id: diva2:1417098
Available from: 2020-03-26 Created: 2020-03-26 Last updated: 2020-03-26Bibliographically approved

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Balgoma, DavidZelleroth, SofiaGrönbladh, AlfhildHallberg, MathiasPettersson, CurtHedeland, Mikael

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