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Histological and histomorphometrical outcome after lateral guided bone regeneration augmentation of the mandible with different ratios of deproteinized bovine bone mineral and autogenous bone: A preclinical in vivo study
Aalborg Univ Hosp, Dept Oral & Maxillofacial Surg, 18-22 Hobrovej, DK-9000 Aalborg, Denmark.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Oral and Maxillofacial Surgery. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Plastic Surgery.
Univ Gothenburg, Sahlgrenska Acad, Inst Surg Sci, Dept Biomat,BIOMATCELL VINN Excellence Ctr, Gothenburg, Sweden; NU Hosp, Org Trollhättan, Dept Oral & Maxillofacial Surg, Trollhättan, Sweden.
Gävle Cty Hosp, Dept Oral & Maxillofacial Surg, Gävle, Sweden.
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2020 (English)In: Clinical Oral Implants Research, ISSN 0905-7161, E-ISSN 1600-0501, Vol. 31, no 10, p. 1025-1036Article in journal (Refereed) Published
Abstract [en]

Objective

To test the hypotheses of no differences in (I) percentage of bone (POB), non‐mineralized tissue (NMT), and deproteinized bovine bone mineral (DBBM), and (II) ingrowth of mineralized bone after lateral guided bone regeneration (GBR) augmentation of the mandible with different ratios of DBBM and particulate autogenous bone (PAB) at different time points.

Material and methods

Twenty‐four minipigs were randomly allocated into three groups. Lateral augmentation in 96 sites (4 in each animal) was performed unilaterally with a standardized quantity of grafting material in each animal with different ratios of DBBM and PAB (50:50, 75:25, 100:0) and autogenous bone block in combination with DBBM and covered with a collagen membrane. The percentage of different tissues in the graft and ingrowth of mineralized bone was assessed by histomorphometrical and histological analyses after 10, 20, and 30 weeks, respectively.

Results

The POB was 54% (50:50), 50% (75:25), and 48% (100:0) after 10 weeks, 60% (50:50), 61% (75:25), and 60% (100:0) after 20 weeks, and 63% (50:50), 62% (75:25), and 62% (100:0) after 30 weeks. There was no significant difference between the groups at any time points. There was a significant increase in POB and a significant decrease in NMT for 75:25 and 100:0 from 10 to 30 weeks. All ratios demonstrated a non‐complete ingrowth of mineralized bone into the graft after 10 weeks and complete mineralization after 30 weeks.

Conclusion

Within the limitations of the present study, it seems like addition of autogenous bone to DBBM for LRA did not affect the bone formation nor graft incorporation after 10–30 weeks of healing. However, a prolonged healing time seems to result in an increased POB for all ratios.

Place, publisher, year, edition, pages
2020. Vol. 31, no 10, p. 1025-1036
Keywords [en]
alveolar bone grafting, alveolar ridge augmentation, biocompatible materials, bone transplantation, GBR, guided bone regeneration, histology
National Category
Dentistry
Identifiers
URN: urn:nbn:se:uu:diva-439194DOI: 10.1111/clr.13649ISI: 000566701400001PubMedID: 32790921OAI: oai:DiVA.org:uu-439194DiVA, id: diva2:1541606
Available from: 2021-04-01 Created: 2021-04-01 Last updated: 2021-04-01Bibliographically approved

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Mordenfeld, Arne

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