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Supplementation with milk enriched with complex lipids during pregnancy: A double-blind randomized controlled trial
Univ Auckland, Liggins Inst, Auckland, New Zealand..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Perinatal, Neonatal and Pediatric Cardiology Research. Univ Auckland, Liggins Inst, Auckland, New Zealand.ORCID iD: 0000-0003-1226-1956
Chongqing Med Univ, Innovat Ctr Social Risk Governance Hlth, Res Ctr Med & Social Dev, Sch Publ Hlth & Management, Chongqing, Peoples R China..
Univ Leicester, Coll Life Sci, Leicester, Leics, England..
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2021 (English)In: PLOS ONE, E-ISSN 1932-6203, Vol. 16, no 2, article id e0244916Article in journal (Refereed) Published
Abstract [en]

Background Gangliosides are a class of sphingolipids that are present in the cell membranes of vertebrates. Gangliosides influence a broad range of cellular processes through effects on signal transduction, being found abundantly in the brain, and having a role in neurodevelopment.

Objective We aimed to assess the effects of maternal daily consumption of ganglioside-enriched milk vs non-enriched milk and a non-supplemented group of pregnant women on maternal ganglioside levels and pregnancy outcomes.

Design Double-blind parallel randomized controlled trial.

Methods 1,500 women aged 20-40 years were recruited in Chongqing (China) between 11 and 14 weeks of a singleton pregnancy, and randomized into three groups: Control-received standard powdered milk formulation (>= 4 mg gangliosides/day); Complex milk lipid-enhanced (CML-E) group-same formulation enriched with complex milk lipids (>= 8 mg gangliosides/day) from milk fat globule membrane; Reference-received no milk. Serum ganglioside levels were measured in a randomly selected subsample of 250 women per group.

Results CML-E milk was associated with marginally greater total gangliosides levels in maternal serum compared to Control (13.02 vs 12.69 mu g/ml; p = 0.034) but not to Reference group. CML-E milk did not affect cord blood ganglioside levels. Among the 1500 women, CML-E milk consumption was associated with a lower rate of gestational diabetes mellitus than control milk [relative risk 0.80 (95% CI 0.64, 0.99)], but which was not different to the Reference group. CML-E milk supplementation had no other effects on maternal or newborn health.

Conclusions Maternal supplementation with milk fat globule membrane, as a source of gangliosides, was not associated with any adverse health outcomes, and did not increase serum gangliosides compared with the non-supplemented reference group.

Place, publisher, year, edition, pages
Public Library of Science (PLoS) Public Library of Science (PLoS), 2021. Vol. 16, no 2, article id e0244916
National Category
Obstetrics, Gynecology and Reproductive Medicine
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URN: urn:nbn:se:uu:diva-441634DOI: 10.1371/journal.pone.0244916ISI: 000623658100029PubMedID: 33626041OAI: oai:DiVA.org:uu-441634DiVA, id: diva2:1553132
Available from: 2021-05-07 Created: 2021-05-07 Last updated: 2024-01-15Bibliographically approved

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Derraik, José G. B.

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