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The Aging Kidney-As Influenced by Heavy Metal Exposure and Selenium Supplementation
Faculty of Health and Social Sciences, Inland Norway University of Applied Sciences, N-2624 Lillehammer, Norway.
Norwegian Institute of Public Health, P.O. Box 222, N-0213 Oslo, Norway.
Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, SE-581 85 Linköping, Sweden.
IM Sechenov First Moscow State Medical University (Sechenov University), Bolshaya Pirogovskaya St., 2-4, 119146 Moscow, Russia.
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2021 (English)In: Biomolecules, E-ISSN 2218-273X, Vol. 11, no 8, article id 1078Article in journal (Refereed) Published
Abstract [en]

The aging process in the kidneys has been well studied. It is known that the glomerular filtration rate (GFR) declines with age in subjects older than 50-60 years. However, there is still insufficient knowledge regarding the response of the aged kidney to environmental toxicants such as mercury, cadmium, and lead. Here, we present a review on the functional decline and proposed mechanisms in the aging kidney as influenced by metal pollutants. Due to the prevalence of these toxicants in the environment, human exposure is nearly unavoidable. Further, it is well known that acute and chronic exposures to toxic metals may be detrimental to kidneys of normal adults, thus it may be hypothesized that exposure of individuals with reduced GFR will result in additional reductions in renal function. Individuals with compromised renal function, either from aging or from a combination of aging and disease, may be particularly susceptible to environmental toxicants. The available data appear to show an association between exposure to mercury, cadmium and/or lead and an increase in incidence and severity of renal disease in elderly individuals. Furthermore, some physiological thiols, as well as adequate selenium status, appear to exert a protective action. Further studies providing improved insight into the mechanisms by which nephrotoxic metals are handled by aging kidneys, as well as possibilities of therapeutic protection, are of utmost importance.

Place, publisher, year, edition, pages
MDPI AG MDPI, 2021. Vol. 11, no 8, article id 1078
Keywords [en]
renal disease, aging; mercury, cadmium, lead, thiols, selenium
National Category
Urology and Nephrology
Identifiers
URN: urn:nbn:se:uu:diva-451877DOI: 10.3390/biom11081078ISI: 000688916900001PubMedID: 34439746OAI: oai:DiVA.org:uu-451877DiVA, id: diva2:1589666
Available from: 2021-08-31 Created: 2021-08-31 Last updated: 2024-01-15Bibliographically approved

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Larsson, Anders

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