uu.seUppsala universitets publikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Fysiologi.
2001 Inngår i: Journal of Clinical Investigation, ISSN 0021-9738, Vol. 108, nr 4, s. 625-633Artikkel i tidsskrift (Fagfellevurdert) Published
sted, utgiver, år, opplag, sider
2001. Vol. 108, nr 4, s. 625-633
Identifikatorer
URN: urn:nbn:se:uu:diva-90655OAI: oai:DiVA.org:uu-90655DiVA, id: diva2:163096
Tilgjengelig fra: 2003-09-09 Laget: 2003-09-09 Sist oppdatert: 2014-04-07bibliografisk kontrollert
Inngår i avhandling
1. The Duodenal Mucosal Bicarbonate Secretion: Role of Melatonin in Neurohumoral Control and Cellular Signaling
Åpne denne publikasjonen i ny fane eller vindu >>The Duodenal Mucosal Bicarbonate Secretion: Role of Melatonin in Neurohumoral Control and Cellular Signaling
2003 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

The duodenal lumen is exposed to aggressive factors with a high potential to cause damage to the mucosa. Bicarbonate secretion by the duodenal mucosa is accepted as the primary important defense mechanism against the hydrochloric acid intermittently expelled from the stomach.

The present thesis concerns the influence of the central nervous system and the effects of the hormone melatonin on bicarbonate secretion in anesthetized rats in vivo. Effects of melatonin on intracellular calcium signaling by duodenal enterocyte in vitro were examined in tissues of both human and rat origin. The main findings were as follows:

Melatonin is a potent stimulant of duodenal mucosal bicarbonate secretion and also seems to be involved in the acid-induced stimulation of the secretion. Stimulation elicited in the central nervous system by the α1-adrenoceptor agonist phenylephrine induced release of melatonin from the intestinal mucosa and a four-fold increase in alkaline secretion. The melatonin antagonist luzindole abolished the duodenal secretory response to administered melatonin and to central nervous phenylephrine but did not influence the release of intestinal melatonin. Central nervous stimulation was also abolished by synchronous ligation of the vagal trunks and the sympathetic chains at the sub-laryngeal level.

Melatonin induced release of calcium from intracellular stores and also influx of extracellular calcium in isolated duodenal enterocytes. Enterocytes in clusters functioned as a syncytium.

Overnight fasting rapidly and profoundly down-regulated the responses to the duodenal secretagogues orexin-A and bethanechol but not those to melatonin or vasoactive intestinal polypeptide.

In conclusion, the results strongly suggest that intestinal melatonin plays an important role in central nervous elicited stimulation of duodenal mucosal bicarbonate secretion. Sensitivity of this alkaline secretion to some peripheral stimulators markedly depends on the feeding status.

sted, utgiver, år, opplag, sider
Uppsala: Acta Universitatis Upsaliensis, 2003. s. 71
Serie
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 0282-7476 ; 1277
Emneord
Physiology, alkaline secretion, central nervous system, duodenal enterocyte, duodenal ulcer, duodenum, enterochromaffin cell, human, intraarterial, intracellular calcium, intracerebroventricular, melatonin, rat, vagal nerve, Fysiologi
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-3521 (URN)91-554-5688-X (ISBN)
Disputas
2003-10-03, B42, BMC, Uppsala, 09:15
Opponent
Veileder
Tilgjengelig fra: 2003-09-09 Laget: 2003-09-09 Sist oppdatert: 2018-01-13bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Personposter BETA

Sjöblom, Markus

Søk i DiVA

Av forfatter/redaktør
Sjöblom, Markus
Av organisasjonen

Søk utenfor DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric

urn-nbn
Totalt: 510 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf