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Electrochemical Methods for Drug Characterisation and Transdermal Delivery: Capillary Zone Electrophoresis, Conductometry, and Iontophoresis
Uppsala University, Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmacy.
2003 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis concerns the development and utilisation of techniques for characterisation and transdermal delivery of various systems for pharmaceutical applications.

The degree of dissociation of drug molecules and the mobilities of the different species formed are essential factors affecting the rate of drug delivery by iontophoresis. Hence, determination of drug mobility parameters and equilibrium constants are important for the development of iontophoretic systems. With capillary zone electrophoresis using a partial filling technique and methyl-β-cyclodextrin as chiral selector, the enantiomers of orciprenaline were separated. The association constants between the enantiomers of the drug and the selector were also evaluated. Precision conductometry studies were performed for the hydrochloride salts of lidocaine and 5-aminolevulinic acid in aqueous propylene glycol and water as media, respectively.

Iontophoresis is a technique for drug delivery where charged molecules are transported into and through skin by application of a weak direct electrical current. The drugs 5-aminolevulinic acid and its methyl ester were used as model compounds and incorporated in two different drug delivery vehicles, a sponge phase and carbopol gel. The bicontinuous structure of the sponge phase, constituted of monoolein and a mixture of propylene glycol and water, makes it interesting for use in iontophoretic delivery, since ions can move more or less freely in the aqueous as well as in the lipid domains. Furthermore, all three components are known for their penetration enhancing abilities. Hydrogels like carbopol gels are interesting media with respect to iontophoretic studies, since devices for iontophoresis often utilize hydrogels as contact interfaces between the skin and the electrodes. The results indicate that the transport achieved iontophoretically using the gel (1 % active substance) was comparable with the passive delivery of clinically used formulations (16 % - 20 % active substance).

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis , 2003. , p. 40
Series
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy, ISSN 0282-7484 ; 302
Keywords [en]
Pharmaceutical chemistry, Capillary zone electrophoresis, precision conductometry, iontophoresis, passive diffusion, lidocaine, ALA, ALA-ester derivatives, sponge phase, carbopol gel
Keywords [sv]
Farmaceutisk kemi
National Category
Medicinal Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-3774ISBN: 91-554-5803-3 (print)OAI: oai:DiVA.org:uu-3774DiVA, id: diva2:163655
Public defence
2003-12-05, B 21, BMC, Husargatan 3, Uppsala, 10:15
Opponent
Supervisors
Available from: 2003-11-14 Created: 2003-11-14 Last updated: 2018-01-13Bibliographically approved
List of papers
1. Determination of association constants between enantiomers of orciprenaline and methyl-β-cyclodextrin as chiral selector by capillary zone electrophoresis using a partial filling technique
Open this publication in new window or tab >>Determination of association constants between enantiomers of orciprenaline and methyl-β-cyclodextrin as chiral selector by capillary zone electrophoresis using a partial filling technique
1999 In: Electrophoresis, Vol. 20, p. 180-188Article in journal (Refereed) Published
Identifiers
urn:nbn:se:uu:diva-91063 (URN)
Available from: 2003-11-14 Created: 2003-11-14Bibliographically approved
2. On iontophoretic delivery enhancement: Electrical conductance and transport properties of lidocaine hydrochloride in aqueous propylene glycol
Open this publication in new window or tab >>On iontophoretic delivery enhancement: Electrical conductance and transport properties of lidocaine hydrochloride in aqueous propylene glycol
2000 In: International Journal of Pharmaceutics, Vol. 201, p. 121-124Article in journal (Refereed) Published
Identifiers
urn:nbn:se:uu:diva-91064 (URN)
Available from: 2003-11-14 Created: 2003-11-14Bibliographically approved
3. Improvements of conductivity measurements of electrolyte solutions using a new conductometric cell design
Open this publication in new window or tab >>Improvements of conductivity measurements of electrolyte solutions using a new conductometric cell design
2002 In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 29, p. 61-67Article in journal (Refereed) Published
Identifiers
urn:nbn:se:uu:diva-91065 (URN)
Available from: 2003-11-14 Created: 2003-11-14Bibliographically approved
4. Transport properties and association behaviour of the zwitterionic drug 5-aminolevulinic acid in water. A precision conductometric study.
Open this publication in new window or tab >>Transport properties and association behaviour of the zwitterionic drug 5-aminolevulinic acid in water. A precision conductometric study.
In: European Journal of Pharmaceutical SciencesArticle in journal (Refereed) Submitted
Identifiers
urn:nbn:se:uu:diva-91066 (URN)
Available from: 2003-11-14 Created: 2003-11-14Bibliographically approved
5. Iontophoretic and passive delivery of 5-aminolevulinic acid (ALA) and its methyl ester (m-ALA) by means of a lipid sponge phase
Open this publication in new window or tab >>Iontophoretic and passive delivery of 5-aminolevulinic acid (ALA) and its methyl ester (m-ALA) by means of a lipid sponge phase
Show others...
Manuscript (Other academic)
Identifiers
urn:nbn:se:uu:diva-91067 (URN)
Available from: 2003-11-14 Created: 2003-11-14 Last updated: 2010-01-13Bibliographically approved
6. Iontophoretic delivery of 5-aminolevulinic acid and its methyl ester using carbopol gel as drug vehicle
Open this publication in new window or tab >>Iontophoretic delivery of 5-aminolevulinic acid and its methyl ester using carbopol gel as drug vehicle
Manuscript (Other academic)
Identifiers
urn:nbn:se:uu:diva-91068 (URN)
Available from: 2003-11-14 Created: 2003-11-14 Last updated: 2010-01-13Bibliographically approved

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