Logo: to the web site of Uppsala University

uu.sePublications from Uppsala University
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Systematic review of quantitative preference studies of treatments for rheumatoid arthritis among patients and at-risk populations
Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, University of Birmingham, Birmingham B15 2WB, UK.ORCID iD: 0000-0003-2596-9101
Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, University of Birmingham, Birmingham B15 2WB, UK.
Janssen Pharmaceuticals, Titusville, NJ, USA.
School of Health Policy & Management, Erasmus University Rotterdam, Rotterdam, The Netherlands; Erasmus Choice Modelling Centre, Erasmus University Rotterdam, Rotterdam, The Netherlands; Julius Center for Health and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Show others and affiliations
2022 (English)In: Arthritis Research & Therapy , E-ISSN 1478-6362, Vol. 24, no 1, article id 55Article in journal (Refereed) Published
Abstract [en]

Treatments used for rheumatoid arthritis (RA) are under investigation for their efficacy to prevent RA in at risk groups. It is therefore important to understand treatment preferences of those at risk. We systematically reviewed quantitative preference studies of drugs to treat, or prevent RA, to inform the design of further studies and trials of RA prevention. Stated preference studies for RA treatment or prevention were identified through a search of five databases. Study characteristics and results were extracted, and the relative importance of different types of treatment attributes was compared across populations. Twenty three studies were included 20 of RA treatments (18 of patients; 2 of the general public) and 3 prevention studies with first-degree relatives (FDRs). Benefits, risks, administration method and cost (when included) were important determinants of treatment choice. A benefit was more important than a risk attribute in half of the studies of RA treatment that included a benefit attribute and 2/3 studies of RA prevention. There was variability in the relative importance of attributes across the few prevention studies. In studies with non-patient participants, attributes describing confidence in treatment effectiveness/safety were more important determinants of choice than in studies with patients. Most preference studies relating to RA are of treatments for established RA. Few studies examine preferences for treatments to prevent RA. Given intense research focus on RA prevention, additional preference studies in this context are needed. Variation in treatment preferences across different populations is not well understood and direct comparisons are needed.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2022. Vol. 24, no 1, article id 55
Keywords [en]
Rheumatoid arthritis, Treatment preferences, Preventive treatment, Attributes, Systematic review
National Category
Social and Clinical Pharmacy
Identifiers
URN: urn:nbn:se:uu:diva-468460DOI: 10.1186/s13075-021-02707-4ISI: 000759580000002PubMedID: 35193653OAI: oai:DiVA.org:uu-468460DiVA, id: diva2:1640682
Projects
IMI-PREFERAvailable from: 2022-02-25 Created: 2022-02-25 Last updated: 2024-07-04Bibliographically approved

Open Access in DiVA

fulltext(1080 kB)402 downloads
File information
File name FULLTEXT01.pdfFile size 1080 kBChecksum SHA-512
c7d098a219c2d60c7ccb7e3faa4cdd79f132b7ace04171b78314f1375947e2b3eff44f91e763326287aa85793739106d44bcbdd758aaa9ccd1890964af86ca7f
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records

Schölin Bywall, KarinKihlbom, Ulrik

Search in DiVA

By author/editor
Simons, GwendaSchölin Bywall, KarinKihlbom, Ulrik
By organisation
Centre for Research Ethics and Bioethics
In the same journal
Arthritis Research & Therapy
Social and Clinical Pharmacy

Search outside of DiVA

GoogleGoogle Scholar
Total: 405 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 394 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf